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EC number: 904-653-0 | CAS number: -
25 ppm estimated to be equivalent to an oral dose of approximately 28 mg/kg bw/day (authors calculation).
The study is comparable to OECD Guideline 412 with acceptable restrictions (the high dose should result in toxic effects; histopathology of a limited number of organs; minor restrictions in hematology and clinical chemistry). According to REACH Regulation (EC) No 1907/2006 Annex VIII an exposure duration of 28 days is recommended.
In a 14 day-inhalation study male and female F344 rats (n=20 per dose per sex) were exposed to phenol vapour by nose-only exposures for 10 exposures (5 days/week, 6 hours/day) at target concentrations of 0, 0.5, 5.0 and 25 ppm (0, 1.9, 19, 96 mg/m³). 10 rats/sex/group were sacrificed after 10 exposures, and after a 14-day recovery time for the remaining animals. No signs of toxicity in clinical observations (including neurological signs), body weights, food consumption, clinical chemistry, haematology, organ weights, macroscopic pathology or microscopic pathology were seen during the exposures or at either sacrifice interval.
Conclusion: Under the conditions of this study no local or systemic toxic effects were detected in rats at exposure concentrations up to 25 ppm (96 mg/m³).
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