Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 904-653-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other:
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study reported in EU-RAR 2006; reliability 2 assumed Phenol is a major component of the reaction mass, so that phenol hazard data are applied in the hazard assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Kania Jr., C.J.
- Year:
- 1 981
- Bibliographic source:
- J. Amer. Med. Technol. 43, 20
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: oral
- acute toxicity: inhalation
- acute toxicity: dermal
- GLP compliance:
- not specified
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
Method
- Route of exposure:
- dermal
- inhalation
- oral
Results and discussion
- Results of examinations:
- Phenol is reported to cause poisoning by skin absorption, vapour inhalation and ingestion. Primary route of entry is the skin. Vapours readily penetrate the skin surface with absorption efficiency equal to that of inhalation. Absorption from spilling phenolic solutions on the skin may be very rapid, and death results from collapse within 30 minutes to several hours. Death has resulted from absorption of phenol through a skin area of 64 inch2. Where death is delayed, damage of the kidneys, liver, pancreas and spleen, and oedema of the lungs may result. The symptoms develop rapidly, frequently within 15-20 minutes following spilling of phenol on the skin. Initial skin contact produces a white wrinkled discoloration with no experience of pain due to the local anaesthetic properties of phenol, with the affected area turning brown and subsequently becoming gangrenous. Prolonged exposure may result in deposition of dark pigment (ochronosis). Phenol vapours are also well absorbed by the lungs. Inhalation causes dyspnea, cough, cyanosis, and pulmonary oedema. Ingestion of even small amounts of phenol causes severe burns of the mouth, esophagus, and abdominal pain. Patches, first white then brown with areas of necrosis, may be noted about the face and oral cavity.
Initial skin contact with phenol produces a white wrinkled discoloration with no experience of pain due to the local anaesthetic properties of phenol, with the affected area turning brown and subsequently becoming gangrenous. Ten percent solutions regularly produce corrosion, and occasionally skin necrosis is seen with solutions as dilute as 1%. Concentrated solutions are severely irritating to the eyes and cause conjunctival swelling with the cornea becoming white and hyperaesthetic; loss of vision has occurred in some cases. Concentration is more critical than volume with respect to local response
Any other information on results incl. tables
Phenol is reported to cause poisoning by skin absorption, vapour inhalation and ingestion. Primary route of entry is the skin. Vapours readily penetrate the skin surface with absorption efficiency equal to that of inhalation. Absorption from spilling phenolic solutions on the skin may be very rapid, and death results from collapse within 30 minutes to several hours. Death has resulted from absorption of phenol through a skin area of 64 inch2. Where death is delayed, damage of the kidneys, liver, pancreas and spleen, and oedema of the lungs may result. The symptoms develop rapidly, frequently within 15-20 minutes following spilling of phenol on the skin. Initial skin contact produces a white wrinkled discoloration with no experience of pain due to the local anaesthetic properties of phenol, with the affected area turning brown and subsequently becoming gangrenous. Prolonged exposure may result in deposition of dark pigment (ochronosis). Phenol vapours are also well absorbed by the lungs. Inhalation causes dyspnea, cough, cyanosis, and pulmonary oedema. Ingestion of even small amounts of phenol causes severe burns of the mouth, esophagus, and abdominal pain. Patches, first white then brown with areas of necrosis, may be noted about the face and oral cavity.
Initial skin contact with phenol produces a white wrinkled discoloration with no experience of pain due to the local anaesthetic properties of phenol, with the affected area turning brown and subsequently becoming gangrenous. Ten percent solutions regularly produce corrosion, and occasionally skin necrosis is seen with solutions as dilute as 1%. Concentrated solutions are severely irritating to the eyes and cause conjunctival swelling with the cornea becoming white and hyperaesthetic; loss of vision has occurred in some cases. Concentration is more critical than volume with respect to local response
Applicant's summary and conclusion
- Conclusions:
- Classification: highly corrosive (causes severe burns)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.