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Acute toxicity tests on aquatic organisms were conducted with the various components of the reaction mass of phenol and 4,4’-isopropylidenediphenol (a.k.a. Bisphenol A). In toxicity tests with aquatic fish, invertebrates, and algae, Bisphenol A was, by in large, the most toxic component of the reaction mass. Thus, the lowest toxicity values reported in acute toxicity tests with fish, invertebrates, and algae were 4.6 mg/L Bisphenol A (based on a 96 -hour LC50 value for fathead minnows), 1.1 mg/L Bisphenol A (based on a 96 -hour EC50 value for mysid shrimp), and 1 mg/L Bisphenol A (based on cell number in a 96 hour toxicity test with the saltwater algae, Skeletonema costatum). Of these toxicity values, the 96-hour EC50 of 1 mg/L for both the saltwater algae, Skeletonema costatum,and the saltwater mysid shrimp, Americamysis bahia, were the lowest reported, and were therefore used in the calculation of the PNEC for aquatic systems.