Registration Dossier

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

Acute toxicity tests on aquatic organisms were conducted with the various components of the reaction mass of phenol and 4,4’-isopropylidenediphenol (a.k.a. Bisphenol A). In toxicity tests with aquatic fish, invertebrates, and algae, Bisphenol A was, by in large, the most toxic component of the reaction mass. Thus, the lowest toxicity values reported in acute toxicity tests with fish, invertebrates, and algae were 4.6 mg/L Bisphenol A (based on a 96 -hour LC50 value for fathead minnows), 1.1 mg/L Bisphenol A (based on a 96 -hour EC50 value for mysid shrimp), and 1 mg/L Bisphenol A (based on cell number in a 96 hour toxicity test with the saltwater algae, Skeletonema costatum). Of these toxicity values, the 96-hour EC50 of 1 mg/L for both the saltwater algae, Skeletonema costatum,and the saltwater mysid shrimp, Americamysis bahia, were the lowest reported, and were therefore used in the calculation of the PNEC for aquatic systems.