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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

When a freshwater species, the fathead minnow (Pimephales promelas), was exposed to Bisphenol A (a.k.a. 4,4’-isopropylidenediphenol), the 96-hour LC50 value was 4.6 mg/L. When a saltwater species, the Atlantic silverside (Menidia menidia), was exposed to Bisphenol A (a.k.a. 4,4’-isopropylidenediphenol), the 96-hour LC50 value was 9.4 mg/L.  These results were selected as key studies, since they were from valid toxicity tests that reported the lowest LC50 values for these parameters.

Key value for chemical safety assessment

LC50 for freshwater fish:
4.6 mg/L
LC50 for marine water fish:
9.4 mg/L

Additional information

One 96-hour acute freshwater fish study with zebrafish (Danio rerio) was available with 2-acetone, polymer with phenol, a mixture of some of the major and minor components of the reaction mass of phenol and 4,4’-isopropylidenediphenol (referred to henceforth as “the reaction mass”). This study was deemed reliable for use in risk assessments (Klimish score = 1). The 96-hour LC50 value for 2-acetone, polymer with phenol was 4.95 mg/L with 95% confidence intervals of 4.07 – 6.00 mg/L. Additionally, fish acute toxicity tests with the two major components of the reaction mass, phenol and 4,4’-isopropylidenediphenol (a.k.a Bisphenol A), were available. These studies were also deemed valid (Klimish score = 1-2). The 96-hour LC50 for rainbow trout (Oncorhynchus mykiss) exposed to phenol is 8.9 mg/L. The 96-hour LC50 values for sheepshead minnow (Cyprinodon variegatus), fathead minnow (Pimephales promelas), and Atlantic silverside (Menidia menidia) exposed to Bisphenol A are 11 mg/L, 4.6 mg/L, and 9.4 mg/L, respectively.

 

The 96-hour LC50 of 4.6 mg/L Bisphenol A with the fathead minnow was the lowest, and thus most conservative, fish acute toxicity value reported for either the major components or a mixture of some of the major and minor components of the reaction mass.