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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
Study discussed in the EU RAR 2003

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1965

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Four male New Zealand albino rabbits, 3 to 5 months of age, were exposed to 6.4 g/kg BPA under impervious sheeting on the clipped intact skin of the trunk for 24 hours. Excess fluid was removed to prevent ingestion and the maximum dosage that could be retained in contact with the skin of the trunk was determined.
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
4,4'-isopropylidenediphenol
EC Number:
201-245-8
EC Name:
4,4'-isopropylidenediphenol
Cas Number:
80-05-7
Molecular formula:
C15H16O2
IUPAC Name:
2,2-bis(4-hydroxyphenyl)propane

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male

Administration / exposure

Type of coverage:
occlusive
Vehicle:
DMSO

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
>= 6 400 mg/kg bw
Mortality:
One of the 4 animals died two days after exposure.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:

Four male New Zealand albino rabbits, 3 to 5 months of age, were exposed to 6.4 g/kg BPA (16 ml/kg of a 40% BPA solution in dimethylsulfoxide) under impervious sheeting on the clipped intact skin of the trunk for 24 hours. Excess fluid was removed to prevent ingestion and the maximum dosage that could be retained in contact with the skin of the trunk was determined. One of the 4 animals died two days after exposure. The authors concluded that the dose of 6.4 g/kg represents the maximum amount of BPA solution that can be retained in contact with the skin of the trunk beneath an impervious covering.