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EC number: 904-653-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study is comparable with OECD Guideline 402 with exceptable restrictions (partly limited documentation, e.g. no details about the test substance and concentration used; pretreatment of exposed skin [intact & abraded] not clearly stated; only 4 rabbits per dose; type of coverage and systemic clinical signs not reported). Phenol is a constituent of the reaction mass so that phenol hazard data are applied in the hazard assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- The benzenediols: catechol, resorcinol and hydroquinone - a review of the industrial toxicology and current industrial exposure limits
- Author:
- Flickinger CW
- Year:
- 1 976
- Bibliographic source:
- Am Ind Hyg Assoc J 37: 596-606
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- Source: Fisher Scientific company, catalogue no. A-91
No further data
Test animals
- Species:
- rabbit
- Strain:
- other: albino, no further data
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No further data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- water
- Details on dermal exposure:
- Abraded skin and intact skin was in contact with the phenol preparation in water for a maximum period of 24 hours (no further data).
- Duration of exposure:
- max. 24 h
- Doses:
- see Table below
- No. of animals per sex per dose:
- 4 males
- Control animals:
- other: yes, untreated animals for assessment of body weight gain in treatment groups
- Details on study design:
- The study was conducted according to the Federal Hazardous Substances Act (FHSA) as published in the Federal Register of August 12, 1961 pages 7333-7341, Part 191. 14 days post exposure observation period. Necropsy performed (at least) in survivors.
- Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 850 mg/kg bw
- 95% CL:
- 600 - 1 200
- Mortality:
- See Table below. Animals in the 2 highest dose groups died the first day after application (other rabbits survived)
- Clinical signs:
- No data on systemic effects.
The aqueous solution of phenol produced necrosis of the skin in all of the exposed rabbits. - Body weight:
- Significant decrease in survivors.
- Gross pathology:
- No internal gross lesions were observed upon autopsy of the sacrificed animals (no futher data).
- Other findings:
- No data
Any other information on results incl. tables
Phenol is a major component of the reaction mass and by its toxicity drives the hazard of the rection mass, so that phenol hazard data are applied in the hazard assessment.
Acute dermal toxicity in males rabbits
Dose in mg/kg bw | Mortality |
250 | 0/4 |
500 | 0/4 |
1000 | 3/4 |
2000 | 4/4 |
Applicant's summary and conclusion
- Conclusions:
- The LD50 in male rabbits in an acute dermal toxicity study was 850 mg/kg bw (95% confidence limits: 600-1200 mg/kg bw).
- Executive summary:
The study is comparable with OECD Guideline 402 with exceptable restrictions (partly limited documentation, e.g. no details about the test substance and concentration used; pretreatment of exposed skin [intact & abraded] not clearly stated; only 4 rabbits per dose; type of coverage and systemic clinical signs not reported).
Four male albino rabbits per dose level received dermal administration of phenol preparations in water for max. 24 h at doses of 250, 500, 1000, or 2000 mg/kg bw. The post exposure observation period was 14 days. Animals in the 2 highest dose groups died the first day after application. No death was reported at 250 and 500 mg/kg bw but body weight gain was decreased. The aqueous solution of phenol produced necrosis of the skin in all of the exposed rabbits. No internal gross lesions were observed upon autopsy of the sacrificed animals.
Conclusion: The LD50 in male rabbits in an acute dermal toxicity study was 850 mg/kg bw (95% confidence limits: 600-1200 mg/kg bw).
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