Registration Dossier
Registration Dossier
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EC number: 904-653-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Neurotoxicity
Administrative data
Description of key information
Specific studies on neurotoxicity are only available on BPA, for which a developmental neurotoxicity study according to OECD guideline 426 reported no evidence of developmental neurotoxicity.
Key value for chemical safety assessment
Additional information
For considerations on the analogue approach used please refer to the reporting form attached to section 13 of the IUCLID.
BPA:
A robust study in rats conducted under OECD and US EPA guidelines (Stump, 2009) reported no evidence of developmental neurotoxicity at any of the tested concentrations of BPA. BPA was continuously administered to rat dams during gestation and lactation via test diets containing 0, 0.15, 1.5, 75, 750, and 2250 ppm BPA. Reduced body weight and body weight gain was observed in dams and F1 males and females at 750 and 2250 ppm BPA. There were no effects observed at any exposure level in the neurobehavioural and neuropathological evaluations of F1 animals. A systemic NOAEL of 75 ppm (corresponding to 5.85 mg/kg/day during gestation and 13.1 mg/kg/day during lactation) for reduction in body weight and weight gain of dams and offspring was determined. A NOAEL for developmental neurotoxicity of 2250 ppm (corresponding to 164 mg/kg/day during gestation and 410 mg/kg/day during lactation) in offspring was determined, as there was no evidence of developmental neurotoxicity at any tested dose, including the highest dose of 2250 ppm BPA.
Justification for classification or non-classification
Classification not warranted based on the hazard profile of the constituents of the reaction mass.
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