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EC number: 904-653-0
CAS number: -
Embryotoxicity in CD-1 mice following maternal
exposure to Phenol
Oral dose in mg/kg bw/day via gavage
Pregant mice at GD 17
Implantation sites per litter
No. of litters with resorptions
No. of litters with dead
%dead fetuses per litter
Live fetuses per litter
Average fetal body weight
The study is comparable to OECD Guideline 414 with acceptable
restrictions (food consumption not examined; no data about corpora
lutea; minor restrictions: no data about acclimatization of mice or age
CD-1 mice received phenol in distilled water via gavage at doses of 0,
70, 140, and 280 mg/kg bw in a volume of 10 ml/kg bw daily during
gestation days (GD) 6 -15. 22 -29 pregnant mice per group were
sacrificed on GD17. Maternal toxicity was observed at the high dose
level including increased mortality (11%), reduced body weight and
reduced weight gain as well as clinical signs like tremor and ataxia. No
effects were detected on prenatal mortality or the incidence of
teratogenic effects in any of the dosed groups, except for an increase
in cleft palate at the highest dose level, a malformation for which the
CD-1 mouse is predisposed under conditions of maternal stress. At 280 mg
phenol/kg bw the mean gravid uterine weight and the average fetal body
weight per litter was statistically significantly reduced.
Conclusion: Development effects like reduced average fetal body weight
and cleft palate were detected at dosages of 280 mg/kg bw/day that also
led to maternal toxicity. The NOAEL for developmental and maternal
effects is 140 mg/kg bw/day.
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