Registration Dossier
Registration Dossier
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EC number: 904-653-0 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Peer-reviewed publication
- Principles of method if other than guideline:
- The stationary phased used was octadecylsilyated
The mobile phase was methanol 0.01 N aqueous HCL mixtures.
HPLC measurements were performed at 30°C with a flow-rate of 2 mL/min (ca. 100 bar). - GLP compliance:
- not specified
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 1.47
- Temp.:
- 30 °C
- Conclusions:
- The log Pow of phenol is 1.47 at 30 °C.
- Executive summary:
Based on the HPLC method the log Pow of phenol is reported to be 1.47 at 30 °C
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- Review of in total 25 results from different studies with various methods
- GLP compliance:
- not specified
- Type of method:
- other: various
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- 1.5
- Temp.:
- 25 °C
- pH:
- 0 - 14
- Remarks on result:
- other: pH not reported
- Conclusions:
- The Pow of phenol is 1.5.
- Executive summary:
In the peer-reviewed paper the Pow of phenol is reported to be 1.5 at 25 °C.
Referenceopen allclose all
Description of key information
The log Pow for phenol is log Pow = 1.5 at 25°C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.5
- at the temperature of:
- 25 °C
Additional information
The octanol/water partition coefficient of a substance with a very similar composition but containing less than 2 wt% phenol was determined using the shake flask method. The Log P >/=3.24. Partition coefficient P >/= 1746.
As this substance contains approx. 40 wt% of phenol, the partition coefficient for phenol is included in the assessment.
The octanol/water partition coefficient for phenol is log Pow = 1.5 at 25°C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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