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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary literature

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Eye irritation for CAS 71-55-6 (1,1,1-trichloroethane)
Author:
INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY (IPCS)
Year:
1990
Bibliographic source:
ENVIRONMENTAL HEALTH CRITERIA 136; INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY (IPCS); 1990
Reference Type:
secondary source
Title:
OECD HPV Chemical Programme, SIDS Dossier approved at SIAM 28
Author:
Epona Associates, LLC
Year:
2009
Bibliographic source:
OECD HPV Chemical Programme, SIDS Dossier approved at SIAM 28 (15-17 April 2009)

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
An eye irritation study of 1,1,1-trichloroethane (CAS No: 71-55-6)was conducted in rabbits to observe its irritation potential.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): Methylchloroform
- Molecular formula: C2H3Cl3
- Molecular weight: 133.405 g/mol
- Substance type: organic
- Physical state: Liquid
- Smiles notation: C(C)(Cl)(Cl)Cl
- InChl: 1S/C2H3Cl3/c1-2(3,4)5/h1H3
Specific details on test material used for the study:
- Name of test material (as cited in study report): Methylchloroform
- Molecular formula: C2H3Cl3
- Molecular weight: 133.405 g/mol
- Substance type: organic
- Physical state: Liquid
- Smiles notation: C(C)(Cl)(Cl)Cl
- InChl: 1S/C2H3Cl3/c1-2(3,4)5/h1H3

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data available

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
Amount : 100 μl
Duration of treatment / exposure:
72 hours

Observation period (in vivo):
7 days
Duration of post- treatment incubation (in vitro):
No data available
Number of animals or in vitro replicates:
No data available
Details on study design:
TEST SITE
- Area of exposure: two drops of liquid onto the right eyeball was installed in rabbit’s eye.

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
7 d
Reversibility:
not specified
Remarks on result:
positive indication of irritation
Remarks:
Slight –moderately Irritating
Irritant / corrosive response data:
Slight to moderate pain and slight conjunctival irritation, but no corneal damage, was reported.

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Conclusions:
The test material 1,1,1-trichloroethane (CAS No:- 71-55-6) was considered to be slightly irritating to the rabbits eye.
Executive summary:

An eye irritation study of 1, 1, 1-trichloroethane (CAS No: 71-55-6) was conducted in rabbits to observe its irritation efficacy.

 

The inhibited and unhibited material was installed in rabbit's eye by introducing two drops of liquid onto the right eyeball. Visual observations of irritation and corneal injury (both internal and external) were made upon the treated eye at the following times after treatment: three minutes, one hour, and one, two, and seven days. 

 

A 5% water solution of fluorescein dye was used to stain and render visible the external injury of the cornea in all observations after the first (three minutes).

 

One application of uninhibited or inhibited 1,1,1-trichloroethane caused slight to moderate pain, slight conjunctival irritation but essentially no corneal damage.

 

On the basis of observed effects,1,1,1-trichloroethane(CAS No:- 71-55-6) can be considered as slightly irritating to the eye of rabbits .