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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary source

Data source

Reference
Reference Type:
review article or handbook
Title:
Skin irritation test of chemical Chloral
Author:
E. I. DUPONT DE NEMOURS AND COMPANY
Year:
1992
Bibliographic source:
TSCATS low detailed report, OTS0571236,year-1992

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as per mentioned below
Principles of method if other than guideline:
Skin irritation test of chemical Chloral (CAS No: 75-87-6) was conducted on guinea pigs at different concentrations.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): Chloral
- Molecular formula: C2HCl3O
- Molecular weight: 147.3879 g/mol
- Substance type: organic
- Physical state: Liquid
- Smiles notation: C(C=O)(Cl)(Cl)Cl
- InChl: 1S/C2HCl3O/c3-2(4,5)1-6/h1H
Specific details on test material used for the study:
- Name of test material (as cited in study report): Chloral
- Molecular formula: C2HCl3O
- Molecular weight: 147.3879 g/mol
- Substance type: organic
- Physical state: Liquid
- Smiles notation: C(C=O)(Cl)(Cl)Cl
- InChl: 1S/C2HCl3O/c3-2(4,5)1-6/h1H

Test animals

Species:
guinea pig
Strain:
not specified
Details on test animals and environmental conditions:
No data

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
2%,5% and 10% of test chemical solution
Duration of treatment / exposure:
No data
Observation period:
No data
Number of animals:
No data
Details on study design:
No data

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Max. score:
10
Reversibility:
no data
Remarks on result:
other: 10% -Strongly irritating
Irritation parameter:
overall irritation score
Basis:
mean
Max. score:
5
Reversibility:
no data
Remarks on result:
other: 5%- Moderately irritating
Irritation parameter:
overall irritation score
Basis:
mean
Max. score:
2
Reversibility:
no data
Remarks on result:
other: 2%- Not irritating

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
A 10% solution was strongly irritating, a 5% solution was mildly to moderately irritating, and a 2% solution was not irritating. Thus on the basis of results obtained, it can be concluded that 2,2,2-trichloroacetaldehyde (CAS No: 75-87-6) can cause irritation at higher concentration and can be considered as irritating to the skin of guinea pigs.
Executive summary:

Skin irritation test was conducted on guinea pigs to evaluate the skin irritant potency of test chemical 2,2,2-trichloroacetaldehyde (CAS No: 75-87-6).

The test chemical was applied skin of guinea pigs at concentration of 2,5 and 10% of test chemical solution and the reactions were read.

A 10% was strongly irritating, a 5% solution was mildly to moderately irritating, and a 2% solution was not irritating.

On the basis of results obtained, it can be concluded that 2,2,2-trichloroacetaldehyde (CAS No: 75-87-6) can cause irritation at higher concentration and can be considered as irritating to the skin of guinea pigs.