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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary source.

Data source

Reference
Reference Type:
secondary source
Title:
Skin sensitization test of TRICHLOROACETALDEHYDE
Author:
E. I. DUPONT DE NEMOURS
Year:
1992
Bibliographic source:
E. I. DUPONT DE NEMOURS, 10/15/1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Skin sensitization test was carried out to study the sensitization potential in the given test chemical.
GLP compliance:
no
Type of study:
guinea pig maximisation test
Justification for non-LLNA method:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichloroacetaldehyde
EC Number:
200-911-5
EC Name:
Trichloroacetaldehyde
Cas Number:
75-87-6
Molecular formula:
C2HCl3O
IUPAC Name:
trichloroacetaldehyde
Constituent 2
Reference substance name:
Chloral
IUPAC Name:
Chloral
Details on test material:
- Name of test material: Chloral
- Molecular formula: C2-H-Cl3-O
- Molecular weight: 147.3879 g/mol
- Substance type: Organic
- Physical state: liquid

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Study design: in vivo (non-LLNA)

Induction
Route:
other: not specified
Vehicle:
other: not specified
Concentration / amount:
not specified
Day(s)/duration:
not specified
Adequacy of induction:
not specified
Challenge
Route:
other: not specified
Vehicle:
not specified
Concentration / amount:
not specified
Day(s)/duration:
not specified
Adequacy of challenge:
not specified
No. of animals per dose:
not specified
Details on study design:
not specified
Challenge controls:
not specified
Positive control substance(s):
not specified

Results and discussion

Positive control results:
not specified

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test chemical
Dose level:
2%
No. with + reactions:
0
Clinical observations:
Allergic contact dermatitis did not developed.not sensitizing
Remarks on result:
no indication of skin sensitisation

Any other information on results incl. tables

Other Details not known

Applicant's summary and conclusion

Interpretation of results:
other: not sensitising
Conclusions:
The given test chemical is not sensitizing to the skin of guinea pig.
Executive summary:

Skin sensitization study was conducted for the given test chemical. A test for sensitization revealed that allergic contact dermatitis did not develop. A 2% solution was not irritating to the skin of guinea pig. It can be concluded that the test chemical is not sensitizing.