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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary source.

Data source

Reference
Reference Type:
secondary source
Title:
Skin sensitization test of TRICHLOROACETALDEHYDE
Author:
E. I. DUPONT DE NEMOURS
Year:
1992
Bibliographic source:
E. I. DUPONT DE NEMOURS, 10/15/1992

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Skin sensitization test was carried out to study the sensitization potential in Trichloroacetaldehyde.
GLP compliance:
no
Type of study:
guinea pig maximisation test
Justification for non-LLNA method:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material: Chloral
- Molecular formula: C2-H-Cl3-O
- Molecular weight: 147.3879 g/mol
- Substance type: Organic
- Physical state: liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): trichloroacetaldehyde
- Molecular formula (if other than submission substance): C2HCl3O
- Molecular weight (if other than submission substance): 147.388 g/mol
- Substance type: organic
- Physical state: liquid
- Purity: no data
- Impurities (identity and concentrations): no data

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data

Study design: in vivo (non-LLNA)

No. of animals per dose:
No data
Details on study design:
No data
Positive control substance(s):
not specified

Results and discussion

Positive control results:
No data available

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test group
Dose level:
2%
No. with + reactions:
0
Clinical observations:
Allergic contact dermatitis did not developed.not sensitizing
Remarks on result:
no indication of skin sensitisation

Any other information on results incl. tables

Other Details not known

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Conclusions:
Trichloroacetaldehyde is not sensitizing to the skin of guinea pig.
Executive summary:

A test for sensitization revealed that allergic contact dermatitis did not develop. A 2% solution was not irritating to the skin of guinea pig.

It can be concluded that theTrichloroacetaldehyde is not sensitizing.