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Registration Dossier
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EC number: 200-911-5 | CAS number: 75-87-6
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Skin sensitization test of TRICHLOROACETALDEHYDE
- Author:
- E. I. DUPONT DE NEMOURS
- Year:
- 1 992
- Bibliographic source:
- E. I. DUPONT DE NEMOURS, 10/15/1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Skin sensitization test was carried out to study the sensitization potential in the given test chemical.
- GLP compliance:
- no
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- not specified
Test material
- Reference substance name:
- Trichloroacetaldehyde
- EC Number:
- 200-911-5
- EC Name:
- Trichloroacetaldehyde
- Cas Number:
- 75-87-6
- Molecular formula:
- C2HCl3O
- IUPAC Name:
- 2,2,2-trichloroacetaldehyde
- Reference substance name:
- Chloral
- IUPAC Name:
- Chloral
- Details on test material:
- - Name of test material: Chloral
- Molecular formula: C2-H-Cl3-O
- Molecular weight: 147.3879 g/mol
- Substance type: Organic
- Physical state: liquid
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- not specified
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: not specified
- Vehicle:
- other: not specified
- Concentration / amount:
- not specified
- Day(s)/duration:
- not specified
- Adequacy of induction:
- not specified
Challenge
- Route:
- other: not specified
- Vehicle:
- not specified
- Concentration / amount:
- not specified
- Day(s)/duration:
- not specified
- Adequacy of challenge:
- not specified
- No. of animals per dose:
- not specified
- Details on study design:
- not specified
- Challenge controls:
- not specified
- Positive control substance(s):
- not specified
Results and discussion
- Positive control results:
- not specified
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 2%
- No. with + reactions:
- 0
- Clinical observations:
- Allergic contact dermatitis did not developed.not sensitizing
- Remarks on result:
- no indication of skin sensitisation
Any other information on results incl. tables
Other Details not known
Applicant's summary and conclusion
- Interpretation of results:
- other: not sensitising
- Conclusions:
- The given test chemical is not sensitizing to the skin of guinea pig.
- Executive summary:
Skin sensitization study was conducted for the given test chemical. A test for sensitization revealed that allergic contact dermatitis did not develop. A 2% solution was not irritating to the skin of guinea pig. It can be concluded that the test chemical is not sensitizing.
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