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Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from computational model developed by USEPA
Qualifier:
according to
Guideline:
other: Modelling database
Principles of method if other than guideline:
Prediction done using ECOSAR v.1.11 model
GLP compliance:
no
Specific details on test material used for the study:
Name of test material: Trichloroacetaldehyde
Molecular formula: C2HCl3O
Molecular weight: 147.3879 g/mol
Physical State: Liquid
Smiles notation: C(C=O)(Cl)(Cl)Cl
InChl : HFFLGKNGCAIQMO-UHFFFAOYSA-N
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
other: Fish
Test type:
not specified
Water media type:
freshwater
Total exposure duration:
96 h
Test temperature:
25 Deg.C
Reference substance (positive control):
not specified
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
646.836 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: ECOSAR Class:Neutral Organics
Validity criteria fulfilled:
not specified
Conclusions:
Based on the EPI Suite ECOSAR version 1.10 prediction model, the 96 hours LC50 was estimated to be 646.836 mg/l on Fish for substance Trichloroacetaldehyde i.e Chloral (CAS no.75-87-6) on the basis of mortality effects.
Executive summary:

Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for test substance Trichloroacetaldehyde i.e Chloral (CAS no.75-87-6) on the basis of effects observed in a static freshwater system. The lethal concentration LC50 value for the substance was estimated to be 646.836 mg/l for fish for 96 hr exposure duration. Based on this lethal value it can be concluded that the substance Trichloroacetaldehyde i.e Chloral (CAS no.75-87-6) can be likely to be non toxic to aquatic environment and thus it is considered as not classified as per the CLP classification criteria.

Description of key information

Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for test substance Trichloroacetaldehyde i.e Chloral (CAS no.75-87-6) on the basis of effects observed in a static freshwater system. The lethal concentration LC50 value for the substance was estimated to be 646.836 mg/l for fish for 96 hr exposure duration. Based on this lethal value it can be concluded that the substance Trichloroacetaldehyde i.e Chloral (CAS no.75-87-6) can be likely to be non toxic to aquatic environment and thus it is considered as not classified as per the CLP classification criteria.

Key value for chemical safety assessment

LC50 for freshwater fish:
646.836 mg/L

Additional information

Four studies including predicted data from validated tools and experimental data from authorative database for short term fish endpoint of test chemical Trichloroacetaldehyde i.e Chloral (Cas no.75 -87-6) with relevant read across which is structurally similar to target were summarised as follows:

 

Using EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program suggest the short term toxicity on fish was predicted for test substance Trichloroacetaldehyde i.e Chloral (CAS no.75-87-6) on the basis of effects observed in a static freshwater system. The lethal concentration LC50 value for the substance was estimated to be 646.836 mg/l for fish for 96 hr exposure duration.

Target prediction assist by experimental result from authorative database of read across chemical 2,2,2-trichloroethanol (Cas no.115-20-8) which suggest that in an acute fish toxicity study, the lethal concentration (LC50) was determined for test substance 2,2,2-trichloroethanol with an exposure period of 96 hrs. on the basis of effects on mortality. Test organism was used as Pimephales promelas (Fathead Minnow) in static freshwater system. Test condition maintained as 45.7 mg/L CaCO3 hardness; 24.9 deg.C test temp.pH 7.5; ALKALINITY:44.0 mg/L CaCO3 and dissolved oxygen 6.9 mg/L.From experiment the Lethal concentration to 50% of test organisms(LC50) on the basis of Mortality effect was observed to be 299 mg/l for exposure period of 96 hrs. (ECOTOX database; 2017)

For the same read across i.e 2,2,2-trichloroethanol (Cas no.115-20-8) another test indicate the lethal concentration (LC50) was determined for test substance 2,2,2-trichloroethanol with an exposure period of 96 hrs. on the basis of effects on mortality. Test organism was used asLepomis macrochirus (Bluegill)in static freshwater system. Test condition maintained as 196 mg/L CaCO3 hardness; 18.7 (18.4-19.1) deg.C test temp., pH 7.98 (7.92- 8.06); ALKALINITY: 172 mg/L CaCO3 and dissolved oxygen 5.79 (5.48 -6.26) mg/L.From experiment the Lethal concentration to 50% of test organisms(LC50) on the basis of Mortality effect was observed to be 201 mg/l for exposure period of 96 hrs.

Above aquatic classification support by one more read across chemical 1,1,1-trichloroethane (Cas no. 71-55-6) which indicate that in an acute fish toxicity study, the lethal concentration (LC50) was determined for test substance 1,1,1-trichloroethane with an exposure period of 96 hrs. on the basis of effects on mortality. Test organism was used as Pimephales promelas (Fathead Minnow) in static freshwater system. Test condition maintained as 12 deg.C test temp., pH 7.8-8.0; and dissolved oxygen >= 5.0 mg/L .From experiment the Lethal concentration to 50% of test organisms(LC50) on the basis of Mortality effect was observed to be 105 mg/l for exposure period of 96 hrs.( ECOTOX database; 2017)

Thus based on the all available lethal concentrations which is in the range 105mg/l to 646.836 mg/l of target and read across chemicals come to the conclusion that test substance Trichloroacetaldehyde i.e Chloral (Cas no.75-87-6) was likely to be non toxic to fish and can be considered to be not classified as per the CLP regulation.