Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Hydrolysis:

Test chemical reacts exothermically with water to form chloral hydrate and the equilibrium constant is 3.6X10-5. On the basis od equilibrium constant value very little test chemical is recovered.

Additional information

Hydrolysis:

Different studies were performed to determine the hydrolysis rate constant and half-life of test chemical and its structurally similar read across chemicals and results are summarized below

 

In first study from authoritative database the test chemical reacts exothermically with water to form chloral hydrate and the equilibrium constant is 3.6X10-5. On the basis of equilibrium constant value very little test chemical is recovered.

 

Another study was conducted to determine the half-life of hydrolysis of test chemical by using different buffers namely MOPS and carbonates. The half-life of hydrolysis of test chemical was determined to be 9 days and 15 days with hydrolysis rate constant of 1.1E-3/h and 1.8E-3/h respectively. On the basis of half-life values test chemical is considered to be hydrolysable.

 

By considering results of both the studies test chemical is considered to be hydrolysable.