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EC number: 200-911-5
CAS number: 75-87-6
Based on the result obtained from the
studies available for the chemical, it can be concluded that the test
chemical cannot cause skin sensitization and thus cannot be considered
as skin sensitizing.
Other Details not known
Skin sensitization study was conducted for
the given test chemical. A test for sensitization revealed that allergic
contact dermatitis did not develop. A 2% solution was not irritating to
the skin of guinea pig. It can be concluded that the test chemical is
In different studies, the given test
chemical has been investigated for the skin sensitization potential to a
greater or lesser extent. The studies are based on in-vivo experiments
conducted in rodents which have been summarized as below -
Skin sensitization study was conducted
for the given test chemical. A test for sensitization revealed that
allergic contact dermatitis did not develop. A 2% solution was not
irritating to the skin of guinea pig. It can be concluded that the test
chemical is not sensitizing.
The above study is supported with
maximization test performed to evaluate the allergic effect of test
chemical in Guinea pig. For induction exposure, 0.1 mL intradermal
injections of test material in olive oil given to Guinea pig. 7 days
after injection, the interscapular region was again shaved, and treated
with w (SLS) =10 %. 8 days later, 0.2 mL of test agent preparation was
occlusively patched on the same region for 48 h. 21 days after the
initial intradermal injection, all animals were challenged by 0.1 mL
test chemical in olive oil was applied to the shaved areas of the guinea
pigs by closed patch test method, and left for 24 h. Reactions were read
24 h and 48 h after removing the patches. No or 0% allergic reaction was
observed after test. Therefore, the substance is considered to be
non-sensitizing to Guinea Pig.
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