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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary source.

Data source

Reference
Reference Type:
secondary source
Title:
Acute oral toxicity for 75-87-6
Author:
REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS)
Year:
2017
Bibliographic source:
REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS),2017

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: As mention below
Principles of method if other than guideline:
Acute oral toxicity study of the given test chemical was performed in Rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichloroacetaldehyde
EC Number:
200-911-5
EC Name:
Trichloroacetaldehyde
Cas Number:
75-87-6
Molecular formula:
C2HCl3O
IUPAC Name:
trichloroacetaldehyde
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): Chloral
- Molecular formula: C2HCl3O
- Molecular weight: 147.3879 g/mol
- Substance type: organic
- Physical state: Liquid
- Smiles notation: C(C=O)(Cl)(Cl)Cl
- InChl: 1S/C2HCl3O/c3-2(4,5)1-6/h1H

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
850 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
850 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality observed
Mortality:
50% mortality was observed at 850 mg/kg bw.
Clinical signs:
Somnolence (general depressed activity); Ataxia and Alteration of classical conditioning were observed in treated rats.
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The acute oral LD50 value was considered to be 850 mg/kg body weight, when rats were treated with the given test chemical orally.
Executive summary:

Acute oral toxicity study was done in rat using test material at dose concentration of 850 mg/kg bw. Animals were observed for mortality and signs of toxicity. 50% mortality observed at dose 850 mg/kg bw. Clinical signs like Somnolence (general depressed activity); Ataxia and Alteration of classical condition were observed. Hence, the acute oral LD50 value was considered to be 850 mg/kg body weight, when rats were treated with the given test chemical orally.

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