Trichloroacetaldehyde

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

toxicity to microorganisms, other

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Data is from secondary source

Justification for type of information:

Data is from secondary source

Qualifier:

according to guideline

Guideline:

other: refer principle below

Principles of method if other than guideline:

Toxicity of test chemical to microrganisms was determined

GLP compliance:

not specified

Analytical monitoring:

no

Vehicle:

not specified

Test organisms (species):

Chilomonas paramaecium

Test type:

static

Water media type:

freshwater

Total exposure duration:

20 h

Reference substance (positive control):

not specified

Duration:

20 h

Dose descriptor:

other: EC5

Effect conc.:

13 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Validity criteria fulfilled:

not specified

Conclusions:

The EC5 value of test chemical was determined to be 13 mg/L after the exposure of test chemical to Microorganism Chilomonas paramaecium for 20 h.

Executive summary:

Toxicity of test chemical to microorganisms was determined by performing the experiment for 20 h, the test microorganism used in the study was Chilomonas paramaecium. The EC5 value of test chemical was determined to be 13 mg/L after the exposure of test chemical to Microorganism Chilomonas paramaecium for 20 h.

Description of key information

Toxicity of test chemical to microorganisms was determined by performing the experiment for 20 h, the test microorganism used in the study was Chilomonas paramaecium. The EC5 value of test chemical was determined to be 13 mg/L after the exposure of test chemical to Microorganism Chilomonas paramaecium for 20 h.

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:

13 mg/L

Additional information

Experimental studies for the test chemical and its read across chemical are reviewed for toxicity for microorganisms endpoint and their results are summarized below.

 

In first study the toxicity of test chemical to microorganisms was determined by performing the experiment for 20 h, the test microorganism used in the study was Chilomonas paramaecium. The EC5 value of test chemical was determined to be 13 mg/L after the exposure of test chemical to Microorganism Chilomonas paramaecium for 20 h.

 

In another study the toxicity of test chemical to microorganisms was determined by performing the experiment for 20 h, the test microorganism used in the study was Entosiphon sulcatum. The EC5 value of test chemical was determined to be 79 mg/L after the exposure of test chemical to Microorganism Entosiphon sulcatum for 20 h.

 

In third study the toxicity of test chemical to microorganisms was determined by performing the experiment for 16 h, the test microorganism used in the study was Pseudomonas putida. The EC3 value of test chemical was determined to be 1.6 mg/L after the exposure of test chemical to Microorganism Pseudomonas putida for 16 h.

 

Next study the toxicity of test chemical to microorganisms was determined by performing the experiment for 20 h, the test microorganism used in the study was Uronema parduzci. The EC5 value of test chemical was determined to be 86 mg/L after the exposure of test chemical to microorganism Uronema parduzci for 20 h.

 

In last toxicity to microorganism study for test material the biological effect was evaluated by using analogous methods of the cell multiplication inhibition test, the toxicity threshold (TT) of test chemical was determined to be 79 mg/l for Entosiphon sulcatum. Therefore EC0 was considered to be <79mg/l for 72h for Entosiphon sulcatum.

 

By considering result of all the studies mentioned above it is concluded that EC 5 value of test chemical is in range of 13 mg/L and 36 mg/L.