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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information


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Description of key information

Key value for chemical safety assessment

Justification for classification or non-classification

Additional information

The International Agency on Research of Cancer (IARC) provides the following evaluation of carcinogenicity of styrene (IARC, 2002):


   There is limited evidence in humans for the carcinogenicity of styrene.

   There is limited evidence in experimental animals for the carcinogenicity of styrene.

   Overall evaluationStyrene is possibly carcinogenic to humans (Group 2B).


In general, IARC attributes the carcinogenic effect of styrene to genotoxic and carcinogenic metabolite of styrene -styrene 7,8-oxide. It is also noted that the possible mechanism of formation of metabolite styrene 7,8-oxide in mice is not likely to operate in humans.