Styrene

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Referred in a recognized source of peer reviewed scientific data on chemicals

Data source

Reference

Reference Type:

publication

Title:

Disposition of [Ring-U-14C]styrene in Rats and Mice Exposed by Recirculating Nose-Only Inhalation.

Author:

Boogaard et al

Year:

2000

Bibliographic source:

Toxicological Sciences Vol.58: 161 -172

Materials and methods

Objective of study:

metabolism

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: Metabolism study

Principles of method if other than guideline:

Study investigated: the disposition, metabolism and genotoxicity potency of styrene after inhalation exposure in rats and mice.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Styrene

EC Number:

202-851-5

EC Name:

Styrene

Cas Number:

100-42-5

Molecular formula:

C8H8

IUPAC Name:

ethenylbenzene

Test material form:

other: vapour

Radiolabelling:

yes

Results and discussion

Any other information on results incl. tables

Study Observed:

 

Studies in Rats:

Clinical Observations:

No signs of toxicity were observed; after holding in metabolism cages for 42 hours after end of exposure; rats appeared healthy; food and water consumption was not affected by the treatment.

 

Excretion:

In total: approx. 80% was excreted

With urine: approx.75% (20% -was excreted during exposure and 55% -was excreted 0 to 42 hours after cessation of exposure)

With feces: approx.1.0%

Exhalled: minor part of metabolism

 

Distribution:

The radioactivity was distributed 45 hours after dosing as follows (descending order): nasal mucosa, small intestine mucosa, harderian gland, skin, liver, kidney cortex, lens, caecum mucosa, intraorbital lachrymal gland, large intestine mucosa, blood, brown fat, preputial gland, white fat, adrenal, lung, stomach mucosa, spleen, bulbourethral gland, thyroid, prostate, kidney medula, aorta, myocardium, mandibular lymph nodes, pancreas, salivary glands, uveal tract, tooth pulp, tongue, pineal body, thymus, pituitary, brain, epididymis, seminal vesicles, muscle, testis, spinal cord, bone marrow.

 

Studies in Mice:

Clinical Observations:

Signs of toxicity, including hunched and unkept appearance was observed at the end of exposure.

 

Excretion:

In total: approx.80% was excreted

With urine: approx.63% (was excreted 0 to 42 hours after cessation of exposure)

With feces: approx.1.0%

Exhalled: minor part of metabolism

 

Distribution:

The radioactivity was distributed 42 hours after dosing as follows (descending order): nasal mucosa, kidney cortex, liver, intraorbital lachrymal gland, lung, skin, testis, uveal tract, salivary glands, blood, caecum mucosa, pituitary, large intestine mucosa, lens, aorta, adrenal, epididymis, brown fat, thyroid, small intestine mucosa, harderian gland, spleen, tongue, kidney medula, stomach mucosa, myocardium, pancreas, pineal body, thymus, mandibular lymph nodes, tooth pulp, exorbital lachrymal gland, seminal vesicles, bone marrow, brain, spinal cord, muscle, white fat.

Applicant's summary and conclusion

Conclusions:

Rapid distribution and excretion were reported for styrene in the study in rats and mice.