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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
sub-chronic toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Referred in a recognized source of peer reviewed scientific data on chemicals

Data source

Reference
Reference Type:
publication
Title:
Toxicological studies of certain alkylated benzenes and benzene: Experiments on laboratory animals.
Author:
Wolf et al.
Year:
1956
Bibliographic source:
AMA Arch Ind Health Vol.14 (4): 387-398.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Subchronic Oral Toxicity Study (Repeated Exposure)
Principles of method if other than guideline:
Subchronic Oral Toxicity Study (Repeated Exposure)
Study investigated: repeated toxicity of styrene to rats via oral administration
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Styrene
EC Number:
202-851-5
EC Name:
Styrene
Cas Number:
100-42-5
Molecular formula:
C8H8
IUPAC Name:
ethenylbenzene

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Study Observed:

At ≥400 mg/kg bw/day: slight to moderate growth depression, slight to moderate effects on liver and kidney weights

LOEL (NOAEL) (rats, oral, 6-month) =400 mg/kg bw/day (effects on body weights, effects on liver & kidney weights) [NOEL =133 mg/kg bw/day]

Applicant's summary and conclusion

Conclusions:
The following No Observed Adverse effect levels could be identified from this study:
LOEL (NOAEL) (rats, oral, 6-month) =400 mg/kg bw/day (effects on body weights, effects on liver & kidney weights) [NOEL =133 mg/kg bw/day]