Registration Dossier
Registration Dossier
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EC number: 202-851-5 | CAS number: 100-42-5
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referred in a recognized source of peer reviewed scientific data on chemicals
Data source
Reference
- Reference Type:
- publication
- Title:
- A study on the mutagenic activity of styrene and styrene oxide.
- Author:
- Vainio et al
- Year:
- 1 976
- Bibliographic source:
- Scand J Work Environ & Health. Vol. 3: 147 -151
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Styrene
- EC Number:
- 202-851-5
- EC Name:
- Styrene
- Cas Number:
- 100-42-5
- Molecular formula:
- C8H8
- IUPAC Name:
- ethenylbenzene
Constituent 1
Results and discussion
Any other information on results incl. tables
Study reported:
Styrene oxide: mutagenic to S typhimurium strains TA1535 and TA100 (with and without metabolic activation); toxic to all tested strains of Salmonella typhimurium at concentration of 10-4moles/plate.
Styrene: equivocal results for mutagenicity, not dose-response effect; toxic to all tested strains of Salmonella typhimurium at concentration of 10-5moles/plate and above.
Applicant's summary and conclusion
- Conclusions:
- Styrene provided equivocal results for mutagenicity in the tested systems.
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