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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Referred in a recognized source of peer reviewed scientific data on chemicals

Data source

Reference
Reference Type:
publication
Title:
A study on the mutagenic activity of styrene and styrene oxide.
Author:
Vainio et al
Year:
1976
Bibliographic source:
Scand J Work Environ & Health. Vol. 3: 147 -151

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 471 (Bacterial Reverse Mutation Assay)
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
Styrene
EC Number:
202-851-5
EC Name:
Styrene
Cas Number:
100-42-5
Molecular formula:
C8H8
IUPAC Name:
ethenylbenzene

Results and discussion

Any other information on results incl. tables

Study reported:

 

Styrene oxide: mutagenic to S typhimurium strains TA1535 and TA100 (with and without metabolic activation); toxic to all tested strains of Salmonella typhimurium at concentration of 10-4moles/plate.

 

Styrene: equivocal results for mutagenicity, not dose-response effect; toxic to all tested strains of Salmonella typhimurium at concentration of 10-5moles/plate and above.

Applicant's summary and conclusion

Conclusions:
Styrene provided equivocal results for mutagenicity in the tested systems.