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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Referred in a recognized source of peer reviewed scientific data on chemicals

Data source

Reference
Reference Type:
publication
Title:
Toxicological studies of certain alkylated benzenes and benzene: Experiments on laboratory animals.
Author:
Wolf et al.
Year:
1956
Bibliographic source:
AMA Arch Ind Health Vol.14 (4): 387-398.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Study investigated: acute toxicity of styrene to rats via oral administration
GLP compliance:
not specified
Test type:
other: acute oral toxicity study

Test material

Constituent 1
Chemical structure
Reference substance name:
Styrene
EC Number:
202-851-5
EC Name:
Styrene
Cas Number:
100-42-5
Molecular formula:
C8H8
IUPAC Name:
ethenylbenzene

Results and discussion

Any other information on results incl. tables

Study Observed:

 

LD50 (rats, oral)= approx. 5000 mg/kg bw

Applicant's summary and conclusion

Conclusions:
Acute oral toxicity of styrene in rats was reported as follows: LD50 (oral, rats)= approx. 5000 mg/kg bw