Styrene

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Referred in a recognized source of peer reviewed scientific data on chemicals

Data source

Reference

Reference Type:

publication

Title:

Toxicological studies of certain alkylated benzenes and benzene: Experiments on laboratory animals.

Author:

Wolf et al.

Year:

1956

Bibliographic source:

AMA Arch Ind Health Vol.14 (4): 387-398.

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

Study investigated: acute toxicity of styrene to rats via oral administration

GLP compliance:

not specified

Test type:

other: acute oral toxicity study

Test material

Test material information

Constituent 1

Reference substance name:

Styrene

EC Number:

202-851-5

EC Name:

Styrene

Cas Number:

100-42-5

Molecular formula:

C8H8

IUPAC Name:

ethenylbenzene

Results and discussion

Any other information on results incl. tables

Study Observed:

 

LD50 (rats, oral)= approx. 5000 mg/kg bw

Applicant's summary and conclusion

Conclusions:

Acute oral toxicity of styrene in rats was reported as follows: LD50 (oral, rats)= approx. 5000 mg/kg bw