Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-851-5 | CAS number: 100-42-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referred in a recognized source of peer reviewed scientific data on chemicals
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological studies of certain alkylated benzenes and benzene: Experiments on laboratory animals.
- Author:
- Wolf et al.
- Year:
- 1 956
- Bibliographic source:
- AMA Arch Ind Health Vol.14 (4): 387-398.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Eye Irritation Study
- Principles of method if other than guideline:
- Study investigated: eye irritation of styrene to rabbits on single eye contact
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Styrene
- EC Number:
- 202-851-5
- EC Name:
- Styrene
- Cas Number:
- 100-42-5
- Molecular formula:
- C8H8
- IUPAC Name:
- ethenylbenzene
Constituent 1
Results and discussion
Any other information on results incl. tables
Study Observed:
Styrene exposure resulted in moderate conjunctival irritation (inflammation and slight swelling of the eyelids) and slight, transient corneal injury (perceptible superficial necrosis involving less than 50% of the cornea).
Applicant's summary and conclusion
- Conclusions:
- Styrene was irriating when applied to rabbits eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
