Registration Dossier

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The report does not contain sufficient information to permit a meaningful evaluation of study results
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
The study methodology followed appeared to equivalent or similar to OECD 405
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium chloride
EC Number:
231-598-3
EC Name:
Sodium chloride
Cas Number:
7647-14-5
Molecular formula:
ClNa
IUPAC Name:
sodium chloride
Details on test material:
- Name of test material (as cited in study report): Salt, common salt, halite, table salt, rock salt, sea salt
- Molecular weight: 58.45

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
not specified in the report

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
100 mg dry powder
Duration of treatment / exposure:
not specified in the report
Observation period (in vivo):
up 72 hours
Number of animals or in vitro replicates:
6 rabbits
Details on study design:
not specified in the report

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24 hours
Score:
18.2
Max. score:
110
Reversibility:
not specified
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 48 hours
Score:
5.3
Max. score:
110
Reversibility:
not specified
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 72 hours
Score:
3.5
Max. score:
110
Reversibility:
not specified
Irritant / corrosive response data:
The mean scores at 24, 48 and 72 hours were 18.2, 5.3 and 3.5 out of a maximum score of 110
Other effects:
not specified in the report

Any other information on results incl. tables

not applicable

Applicant's summary and conclusion

Interpretation of results:
no data
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
The report does not contain sufficient information on the interpretation of the scores so obtained at 24, 48 and 72 hours.
Executive summary:

Eye irritation was evaluated in rabbits and the study methodology followed appeared to equivalent or similar to OECD 405. The report does not contain sufficient information on the interpretation of the scores so obtained at 24, 48 and 72 hours.