Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The report contains sufficient information to permit a meaningful evaluation of study results
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
The study methology followed appeared to be equivalent or similar to the standard acute method
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium chloride
EC Number:
231-598-3
EC Name:
Sodium chloride
Cas Number:
7647-14-5
Molecular formula:
ClNa
IUPAC Name:
sodium chloride
Details on test material:
- Name of test material (as cited in study report): Salt, common salt, halite, table salt, rock salt, sea salt
- Molecular weight: 58.45

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified in the report

Administration / exposure

Type of coverage:
not specified
Vehicle:
water
Details on dermal exposure:
Sodium chloride was moistened with sufficient water to make a paste
Duration of exposure:
not specified in the report
Doses:
10000 mg/kg
No. of animals per sex per dose:
5 rabbits
Control animals:
not specified
Details on study design:
not specified in the report
Statistics:
not specified in the report

Results and discussion

Preliminary study:
not applicable
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Based on:
test mat.
Mortality:
no mortality was observed
Clinical signs:
other: no signs of toxicity observed
Gross pathology:
no significant findings were noted at necropsy
Other findings:
slight erythema was observed

Any other information on results incl. tables

not applicable

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Based on the results of the study, sodium chloride is not classified according to EU Annex VI.
Executive summary:

A dermal toxicity study was conducted in rabbits and the LD50 value was greater than 10000 mg/kg and hence not classified according to EU Annex VI