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EC number: 231-598-3 | CAS number: 7647-14-5
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
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- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
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Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: case report
- Adequacy of study:
- supporting study
- Study period:
- 2009
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: It is a case study report of Acute gastric ulcer. There is no specific guideline followed mentioned in the report.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- other: Case report
- Title:
- Unnamed
- Year:
- 2 009
Materials and methods
- Study type:
- clinical case study
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium chloride
- EC Number:
- 231-598-3
- EC Name:
- Sodium chloride
- Cas Number:
- 7647-14-5
- Molecular formula:
- ClNa
- IUPAC Name:
- sodium chloride
- Details on test material:
- - Name of test material (as cited in study report): Sodium Chloride
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed:
- Sex:Male
- Age:20 year old - Ethical approval:
- not specified
- Route of exposure:
- oral
- Reason of exposure:
- unintentional, non-occupational
- Exposure assessment:
- measured
- Details on exposure:
- A 20-year old Soldier was admitted to the emergency department, complaining of acute epigastric pain, vomitting and afebrile watery diarrhea, which appeared 48 hours after ingestion of a small ladle of coarse salt mixed with a small amount of sparkling wine.
- Examinations:
- Clinical examination
Blood count
Electrocardiography
Chest x-radiography
Abdominal ultrasound
Endoscopy of the upper digestive tract - Medical treatment:
- Intravenous proton pump inhibitors (PPIs)-40mg/d and Sucralfate-4g/d
Results and discussion
- Clinical signs:
- Acute epigastric pain, vomiting and afebrile watery diarrhea.
- Results of examinations:
- Results of clinical examination, blood count, electrocardiography, chest x-radiography and abdominal ultrasound were normal. On day 3 after ingestion, endoscopy of the upper digestive tract showed intense congestive antral gastritis and a deep antral ulcer, surrounded by smaller ulcers around its entire circumference with no other abnormalities. The duodenal bulb and descending duodenum were macroscopically normal. Biopsies taken at the edge of the largest ulcer showed edema and serosal congestion with blood extravasation and central fibrinoid necrosis. No malignancy, no chronic gastritis, and no H.pylori infection observed. Epigastric pain disappeared after 7 days of treatment by intravenous protop pump inhibitors (PPIs) (40mg/d) and sucralfate (4g/d) begun just before endoscopy in the emergency unit. Endoscopic examination on day 7 still showed the large deep antral ulcer, but less marked congestive antritis. Both had healed by day 70 of PPI treatment.
- Effectivity of medical treatment:
- Endoscopic examination on day 7 still showed the large deep antral ulcer, but less marked congestive antritis. Both had healed by day 70 of PPI treatment.
- Outcome of incidence:
- Chronic ingestion of salt induces chronic gastritis, which can promote the development of gastric cancer in men. The digestive consequences of acute salt ingestion in humans are not well knwon. The case study reports the gastric lesions in young man, induced by accidental ingestion of coarse salt.
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Conclusions:
- The first reported human case of acute gastric toxicity induced by ingestion of a coarse salt solution (nearly 16 grams) of smaller volume (0.23g/kg versus 0.5 to 1 g/kg) but higher concentration than in animal experiments. This concentration explains the gastric lesions. The potential severe gastric toxicity of coarse salt, a common ingredient.
- Executive summary:
A 20 -year-old soldier was admitted to the emergency department, complaining of acute epigastric pain, vomiting, and afebrile watery diarrhea, which appeared 48hours after ingestion of a small ladle of coarse salt mixed with a small amount of sparkling wine.
Results of the clinical examination, blood count, electrocardiography, chest X-radiography, and abdominal ultrasound were normal. On day 3 after ingestion, endoscopy of the upper digestive tract showed intense congestive antral gastritis and a deep antral ulcer, surrounded by smaller ulcers around its entire circumference, with no other abnormalities. The duodenal bulb and descending duodenum were macroscopically normal. Biopsies taken at the edge of the largest ulcer showed edema and serosal congestion with blood extra vasation and central fibrinoid necrosis. No malignancy, no chronic gastritis, and no H.Pylori infection was observed. Epigastric pain disappeared after 7 days of treatment by intravenous protop pump inhibitors (PPIs) (40 mg/d) and sucralfate (4g/d) begun just before endoscopy in the emergency unit. Endoscopic Examination on day 7 still showed the large deep antral ulcer, but less marked congestive antritis. Both had healed by day 70 of PPI treatment.
The first reported human case of acute gastric toxicity induced by ingestion of a coarse salt solution (nearly 16 grams) of smaller volume (0.23g/kg versus 0.5 to 1 g/kg) but higher concentration than in animal experiments. This concentration explains the gastric lesions. The potential severe gastric toxicity of coarse salt, a common ingredient.
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