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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets

Toxicological information

Health surveillance data

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Administrative data

health surveillance data
Type of information:
experimental study
Adequacy of study:
supporting study
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: The study is a review article of comaprision of salts,the study did not mention any guidelines.The interpretation of results comes from the survey data.
Reason / purpose for cross-reference:
reference to same study

Data source

Reference Type:
review article or handbook
Sodium and potassium
Melvin J.fregly
Bibliographic source:
Ann.rev.Nutr. 1981.1:69-93

Materials and methods

Study type:
human medical data
Test guideline
no guideline required
Principles of method if other than guideline:
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium chloride
EC Number:
EC Name:
Sodium chloride
Cas Number:
Molecular formula:
sodium chloride
Constituent 2
Reference substance name:
Details on test material:
No data


Type of population:
Ethical approval:
not specified
Details on study design:
No data

Results and discussion

The infants who recieved NaCl instead of sugar in their formula ingested sodium at a concentration of 2000-2500 mEq/Liter (116-146 g of NaCl/liter).The 3g/kg of sodium chloride is lethal and smaller amounts have known to kill.Another author suggested thet the probable lethal dose for adult human ranges from 0.5 to 5.0 g/Kg..The visible edema occurs in the healthy adult man with 35-40 g of NaCl per day when consuming an ordinary diet.

Any other information on results incl. tables


Applicant's summary and conclusion

The probable lethal dose for adult ranges from 0.5 to 5.0 g/kg .The visible edema occurs in the healthy adult man with 35-40 g of NaCl per day.
Executive summary:

This is a review article on the acute toxicity of sodium chloride.The study was done the general people and infant where NaCl was accidently used in place of sugar in preparing infant feeding formulas.deaths have also resulted from its use as an emetic where vomiting where vomiting did not occur.The use of hypertonic saline injuctions to induce abortion has also resulted in the death of the of some women. In addition, an excessively high concentration of sodium ions resulting from sodium bicarbonate therapy for salicylate poisoning or for excessive diarrhea and vomiting in infants has produced permanent brain damage and other pathologic effects . The major pathologic findings in deaths resulting from NaCl toxicity were subarachnoid hemorrhages and multiple small intracerebral hemorrhages, shrinkage of the convoluted tubular cells from the basement membrane of the kidneys, and diffuse reddening of the mucosa of the stomach and small intestine.

The author stated that 3 g/kg is regarded as lethal and that smaller amounts have been known to kill. The probable lethal dose for adult humans ranges from 0.5 to 5.0 g/kg. The visible edema occurs in the healthy adult man with 35-40 g of NaCI per day.