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EC number: 231-598-3
CAS number: 7647-14-5
No information available
Historically, sodium chloride (as a major ingredient in edible salt) has
been commonly used in cooking and as a condiment and food preservative.
Sodium chloride is categorised under GRAS (Generally Recognised as Safe)
by the FDA (U.S. Food and Drug Administration) and the average daily
levels of sodium intake for adults range from 2 to 5 grams. A technical
report by WHO and the Food and Agriculture Organization (FAO)
recommended the consumption of less than 5 grams sodium chloride (or 2
grams sodium) per day as a population nutrient intake goal, while
ensuring that the salt is iodized (WHO, 2003).
Reproductive toxicity studies were not performed on sodium chloride, due
to the ubiquitous human exposures (oral and dermal) to NaCl without
causally related reproductive effects, animal testing is not necessary.
High oral sodium chloride intake is associated with increased risk of
hypertension; however, this is a well studied field in humans and
additional animal testing data would not add value.
Exposure Aspects: The contact of humans to sodium chloride due to
handling in or at the workplace may involve incidental dermal exposure,
which is controlled by skin protection measures. The systemic exposure
to sodium chloride caused by such incidental skin contact is judged to
be irrelevant compared to the daily intake and the accepted exposure
during swimming in the sea.
Sodium chloride is not classified as a developmental toxicant.
Developmental toxicity studies were not performed on sodium chloride, as
pregnant women typically consume several grams of salt per day (oral
exposure) and potentially have dermal exposure to 2-3% NaCl in saltwater
when bathing in the ocean. Due to the ubiquitous human
exposures to NaCl without causally related developmental effects, animal
testing is not necessary. High oral sodium chloride intake is associated
with increased risk of hypertension; however, this is a well studied
field in humans and additional animal testing data would not add value.
No information available
chloride is not formally classified in the EU (according to Regulation
EC No. 1272/2008 Annex VI, Table 3.1 and Regulation EC No. 1272/2008
Annex VI, Table 3.2) and UN-GHS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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