Registration Dossier
Registration Dossier
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EC number: 231-598-3 | CAS number: 7647-14-5
Endpoint summary
Administrative data
Description of key information
Additional information
Sodium chloride is used as a reference material in numerous testing of aquatic toxicity, e.g. for method evaluation. The studies summarised in this dataset have focused on testing in line following international guidelines, i.e. does not aim at giving a comprehensive review of the literature.
From the available data, a conclusion on differences in sensitivity between vertebrates (fish), invertebrates (Daphnia) and Algae and Cyanobacteria, is not apparent. From a point of view of acute toxicity, fish were found to be most tolerant over a 96 exposure period, as reported by several authors from parallel testing (e.g. Birge et al., 1985, Patrick et al., 1968). However, in a 33 day early life stage study with Pimephales promelas, the most sensitive endpoint was survival with a NOEC of 252 mg/L.
For Daphnia, the acute EC50 (24h, 874 mg/L) is an order of magnitude lower than for fish, the 21 day NOEC (based on reproduction and other parameters with Daphnia pulex) is 314 mg/L. A similar short term EC50 was observed with tubifex tubifex EC50 (96h)= 781 mg/L in an non standard test. No chronic toxicity is available for tubifex. Other species tested demonstrated enormous tolerance to sodium chloride during short term exposure.
For Algae, the diatom Nitzschia linearis was found most sensitive with an EC50 (120 h, cell number) of 2430 mg/L from four different species tested. Unfortunately, the effect data is not reported and a NOEC can not be derived and is not reported in the article.
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