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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study report contains sufficient information to permit a meaningful evaluation of study results
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
The study methodology followed was equivalent or similar to standard acute method
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium chloride
EC Number:
231-598-3
EC Name:
Sodium chloride
Cas Number:
7647-14-5
Molecular formula:
ClNa
IUPAC Name:
sodium chloride
Details on test material:
- Name of test material (as cited in study report): Salt, common salt, halite, table salt, rock salt, sea salt
- Molecular weight: 58.45

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals or test system and environmental conditions:
not specified in the report

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
not specified
Vehicle:
other: aqueous solution
Details on inhalation exposure:
42 mg/l adminsitered as an aerosol of a 20% (w/v) aqueous solution
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
1 h
Concentrations:
42 mg/l adminsitered as an aerosol of a 20% (w/v) aqueous solution
No. of animals per sex per dose:
6 male rats
Control animals:
not specified
Details on study design:
not specified in the report
Statistics:
not specified in the report

Results and discussion

Preliminary study:
not applicable
Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
> 42 mg/L air
Based on:
test mat.
Exp. duration:
1 h
Mortality:
no mortality observed
Clinical signs:
other: no clinical signs of toxicity observed
Body weight:
not specified in the report
Gross pathology:
no significant findings noted at necropsy
Other findings:
not applicable

Any other information on results incl. tables

not applicable

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Based on the results of the study, the LC50 of sodium chloride administered as an aerosol of a 20% aqueous solution to male rats was greater than 42 mg/l and hence not classified.
Executive summary:

An acute inhalation toxicity study was conducted at a dose of 42 mg/l administered as an aerosol of a 20% aqueous solution to male rats and the results of the study indicated that the LC50 of sodium chloride was greater than 42 mg/l and hence not classified.

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