Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

From Read across source substance Triglyme: LC50, Danio rerio: > 5000 mg/L
Supporting study from Monoglyme: Toxic threshold (48h), Leuciscus idus: > 1000 mg/L
LC50, Leuciscus idus: > 500 mg/L

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Dose descriptor:
Effect concentration:
> 5 000 mg/L

Additional information

Under 13.2 attached is the justification for read across to existing data from triethylene glycol dimethyl ether (Triglyme, CAS 112-49-2) as an appropriate source molecule. It is hypothesized that triglyme can be used as analogue to monoglyme, because they share the same toxic mode of action so that read across among each other can be used to assess the acute aquatic toxicity of the individual members.The appropriateness of the chosen source molecule is based on structural and functional similarities, comparable physicochemical properties, common metabolic pathway(s), and a similar mode of action indicating a comparable ecotoxicological profile for monoglyme as the target substance and triglyme as the source substance.

The read across key-study from Triglyme with Danio rerio and the supporting information from monoglyme in Leuciscus idus are available for acute toxicity to fish. The most reliable LC50 determined was > 5000 mg/L.