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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

NOEC, Daphnia magna: 320 mg/L

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Dose descriptor:
Effect concentration:
320 mg/L

Additional information

Under 13.2 attached is the justification for read across to existing data from diethylene glycol dimethyl ether (Diglyme, CAS 111-96-6) as an appropriate source molecule. It is hypothesized that diglyme can be used as analogue to monoglyme, because they share the same toxic mode of action so that read across among each other can be used to assess the acute aquatic toxicity of the individual members.The appropriateness of the chosen source molecule is based on structural and functional similarities, comparable physicochemical properties, common metabolic pathway(s), and a similar mode of action indicating a comparable ecotoxicological profile for monoglyme as the target substance and diglyme as the source substance.

One read across key-study is available for the source substance diglyme with Daphnia magna for chronic toxicity to daphnia (21 d). The determined NOEC was 320 mg/L. All results are shown in the "short description of key information" field.