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EC number: 203-794-9
CAS number: 110-71-4
Ethylene glycol dimethyl ether was tested for its skin irritant
properties in 6 Himalayan rabbits. The study was performed according to
OECD Guideline 404. Deviations were the absence of the recovery period
of 14 days and a prolonged exposure period (24 hours). These conditions
make the study design more rigid compared to the regarding OECD
Guideline. Effects skin (erythema grades up to 4 and edema scores up to
2) were observed in all animals 48 hour after application. These signs
were not reversible within the 72 hours observation period.
With reference the reported scores and the absence reversibility of the
observed effects Ethylene glycol dimethyl ether has to be classified as
irritant to the skin (R38 - irritant to skin; H315 - causes skin
irritation, skin irritant category 2) according to the criteria laid
down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU
Classification Labelling and Packaging Regulation (1272/2008/EC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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