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EC number: 203-794-9
CAS number: 110-71-4
Several in vitro assays for genetic toxicity were performed:
- Ames test: negative- in vitro SCE test: positive (restricted reliability)- in vitro UDS assay: negative (2 studies)- in vitro gene mutation test: negative
Two genetic toxicity studies have been performed:
- in vivo micronucleus test in mice: negative- in vivo Chromosome Aberration study in hamsters: negative
A bacterial reverse mutation assay (Ames test) has been performed on Ethylene glycol dimethyl ether covering the strains Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA1538 and E. coli WP2 uvr A. There was no increase in the number of revertant colonies with any of the tester strains.
In two mammalian cytogenicity studies the genotoxic potential of Ethylene glycol dimethyl ether was examined in vitro using Chinese hamster cells for the detection of sister chromatid exchanges and the permanent human cell line A549 for determination of unscheduled DNAsynthesis, negative results in the absence of metabolic activation were obtained for the human cell line and positive in case of the Chinese hamster cells. Ethylene glycol dimethyl ether did not induce chromosome aberrations at 2000 mg/kg bw in an in vivo Mammalian Bone Marrow Chromosome Aberration test performed with hamsters similar to OECD475. Furthermore, Ethylene glycol dimethyl ether is considered to be non-mutagenic in mice in the micronucleus test applying dosages up to 2000 mg/kg d (at 2 applications on 2 consecutive days).
Endpoint Conclusion: No adverse effect observed (negative)
It can be concluded from the data available that mutagenicity and
genotoxicity are not caused by Ethylene glycol dimethyl ether and
therefore classification for this end point is not warranted.
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