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EC number: 203-794-9
CAS number: 110-71-4
A develpomental inhalation toxicity study was performed in pregnant rabbits. The animals were exposed to an Ethylene glycol dimethal ether atmosphere of 0, 5 (0.019 mg/L), 16 (0.06 mg/L) and 50 ppm (0.187 mg/L) on gestations days 6 to 18.
All animals survived. With the exception of one abortion in the 16 ppm dose group no serious clinical signs were noted at any dose level. The urine of one rabbit at the 16 ppm level was stained red on day 9 of gestation. Body weight gain of all animals in the 0, 5 and 16 ppm dose group was not affected. During the first week of treatment the body weight of the animals of the 50 ppm dose group was decreased. Within the second week of treatment this effect disappeared. There were no effects upon the mean daily food consumption observed at the 5 ppm dose level. The food consumption of the animals of the 50 ppm and 16 ppm dose level was slightly decreased during the exposure period. The effect diminished after the last treatment. The organ weights were within the control range. No changes occurred at any dose level with the exception of one abortion in the 16 ppm dose group. Grey areas on the kidney surface were found in one control animal, 4 animals of the 5 ppm dose group, 2 animals of 16 ppm dose group and 1 animal of the high dose group.
There was no effect on foetal development and body weight observed at any dose level. Sex ratio was regular. The vitality of the litters within the first 24 hours after Caesarean section at 50 ppm exposure was considerably decreased. One foetus of the control group had an abnormal orientation of the fore-paws and an umbilical hernia. In the 5 ppm dose group 3 foetuses with skull malformations were found. One foetus of the 16 ppm dose level showed a retarded skeletal development and multiple malformations of skull, spine and extremity (left fore-paw almost completely missing). In the 50 ppm dose group 10 foetuses had an abnormal orientation of one or both fore-paws. Two foetuses showed skull malformations. Irregularity of the skull ossification was observed in 2 foetuses of the control group, 1 foetus of the 5 ppm dose group, 3 foetuses of the 16 ppm group and 8 foetuses of the high dose group. There was an increased incidence of rib anomalies combined with an increased dosage (statistically significant). The skeletal development of viable foetuses was not affected by treatment compared to the control group. Cases of lung anomalies and blood within the chest were present in all groups. Enlarged stomachs were observed in the 16 ppm and 50 ppm dose groups as well as in the control group. 2 foetuses of the high dose group had red-bordered spots on the skin (mandible, neck and below the eyes).
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