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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1981
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study according to OECD402; no individual data reported

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
yes
Remarks:
only one sex tested, limitations in study reporting
Principles of method if other than guideline:
acute dermal toxicity after single application
GLP compliance:
no
Remarks:
performed before GLP guidelines
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Monoethylenglykoldimethylether
IUPAC Name:
Monoethylenglykoldimethylether
Constituent 2
Chemical structure
Reference substance name:
1,2-dimethoxyethane
EC Number:
203-794-9
EC Name:
1,2-dimethoxyethane
Cas Number:
110-71-4
Molecular formula:
C4H10O2
IUPAC Name:
1,2-dimethoxyethane
Details on test material:
- Name of test material (as cited in study report): Monoethylenglykoldimethylether
- Analytical purity: not stated
- physical state: clear colourless liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Hoechst AG, Kastengrund, SPF breed
-Strain: Hoe WISKf(SPF71)
- Age at study initiation: no data
- Weight at study initiation: 170 - 176 g (female animals); (mean = 172,7 g; s = ± 2,42; n = 6)
- Diet (e.g. ad libitum): Altromin 1324 ad libitum
- Water (e.g. ad libitum): Tap water ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
- Housing: single, in plastic cages, softwood pellets

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: 30 cm2
- % coverage: 100
- Type of wrap if used: aluminium foil (6 x 8 cm) fixed with elastic bandage (Elastoplast, 8 cm)

Duration of exposure:
24 hours
Doses:
5000 mg/kg body weight
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: clinical observation after application; weighing once weekly
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, mortality

Results and discussion

Preliminary study:
no preliminary study performed
Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Mortality:
No mortality
Clinical signs:
other: No clinical symptoms detectable.
Gross pathology:
No macroscopic visible changes.
Other findings:
No further findings.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Conclusions:
The median lethal dose (LD50) of monoethylenglykol dimethylether is greater 5000 mg/kg body weight in female rats.
Executive summary:

The median lethal dose (LD50) of monoethylenglykol dimethylether is greater 5000 mg/kg body weight in female rats. Therefore monoethyleneglycol dimethyl ether is classified as practically nontoxic.