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EC number: 203-585-2 | CAS number: 108-46-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in mammalian cells
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 476 (In Vitro Mammalian Cell Gene Mutation Test)
- GLP compliance:
- yes
- Type of assay:
- other: thymidine kinase locus
Test material
- Reference substance name:
- Resorcinol
- EC Number:
- 203-585-2
- EC Name:
- Resorcinol
- Cas Number:
- 108-46-3
- Molecular formula:
- C6H6O2
- IUPAC Name:
- resorcinol
- Details on test material:
- Resorcinol (AO11), >95% purity
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- mouse lymphoma L5178Y cells
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- 5, 6, 7, 8, 9, and 10 mM (without S9, Experiments 1 and 2)
0.313, 0.625, 1.25, 2.5, 5 and 10 mM (with S9 Experiment 1)
5, 6, 7, 8, 9 and 10 mM (with S9 Experiment 2) - Vehicle / solvent:
- The test item was dissolved in dimethylsulfoxide (DMSO).
Controls
- Negative solvent / vehicle controls:
- yes
- Remarks:
- Dimethylsulfoxide (DMSO
- Positive controls:
- yes
- Remarks:
- Methylmethane sulfonate (MMS); cyclophosphamide (CPA)
- Details on test system and experimental conditions:
- Type: other: thymidine kinase locus
Results and discussion
Test resultsopen allclose all
- Key result
- Species / strain:
- mouse lymphoma L5178Y cells
- Metabolic activation:
- without
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Positive controls validity:
- not specified
- Key result
- Species / strain:
- mouse lymphoma L5178Y cells
- Metabolic activation:
- with
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Positive controls validity:
- not specified
Any other information on results incl. tables
Preliminary
Toxicity Study: Without S9:
Following
the 3-hour treatment without S9 mix, a moderate to marked toxicity was
noted at dose-levels = 1 mM (50-75% decrease in adjusted relative
suspension growth (Adj. RSG) and up to 50-69% decrease in adjusted
relative total growth (Adj. RTG)).
Main study:
Without
S9: In
both experiments, a moderate to marked toxicity was noted at all
dose-levels as shown by 54-76% decrease in Adj. RSG and 46-83% decrease
in Adj. RTG.
Noteworthy increases in the mutation frequency (up to 4.8-fold the
vehicle control value) were observed following the 3-hour treatment in
both experiments.
With S9:
A
slight to marked toxicity was observed at dose-levels = 5 mM, as shown
by 30-78% decrease in Adj. RSG and 28-65% decrease in Adj. RTG
In the First experiment:
a
slight increase in the mutation frequency was noted at the dose-level of
10 mM. Since this very slight increase which did not reach the 2-fold
level was neither dose-related nor reproducible in the second
experiment, it was not considered as biologically relevant.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: positive
Under these experimental conditions, Resorcinol (A011) induced mutagenic activity in the mouse lymphoma assay, without metabolic activation (S9 mix)
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