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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No additional details available. Included due to prior inclusion in SIAR.

Data source

Reference
Reference Type:
publication
Title:
Unknown
Author:
Thomas and Gisburn
Year:
1961
Bibliographic source:
Br. J. Dermatol. 73:378-381

Materials and methods

Test guideline
Qualifier:
no guideline available

Test material

Constituent 1
Chemical structure
Reference substance name:
Resorcinol
EC Number:
203-585-2
EC Name:
Resorcinol
Cas Number:
108-46-3
Molecular formula:
C6H6O2
IUPAC Name:
benzene-1,3-diol
Details on test material:
12.5% Resorcinol in a topical ointment

Method

Ethical approval:
not specified
Details on study design:
One female
Details on exposure:
ca. 500g/week of an ointment containing 12.5 % resorcinol, for 13 years to an open leg ulcer

Results and discussion

Results:
In one female patient with leg ulcers treated dermally for 13 years with ca. 500g/week of an ointment containing 12.5 % resorcinol, 2.1 % of the applied dose was found in urine as glucuronide and monosulphate metabolites.

Applicant's summary and conclusion

Conclusions:
In one female patient with leg ulcers treated dermally for 13 years with ca. 500g/week of an ointment containing 12.5 % resorcinol, 2.1 % of the applied dose was found in urine as glucuronide and monosulphate metabolites.