resorcinol; 1,3-benzenediol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Provides basic data

Data source

Reference

Reference 1

Reference Type:

publication

Title:

The benzenediols: catechol, resorcinol and hydroquinone - a review of the industrial toxicology and current industrial exposure limits.

Author:

Flickinger, C.W.

Year:

1976

Bibliographic source:

American Industrial Hygiene Association Journal, 37:596-606.

Report date:

1976

Reference 2

Reference Type:

other: Internal Document

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Test guideline

Guideline:

other:

Principles of method if other than guideline:

Method: other

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Resorcinol

EC Number:

203-585-2

EC Name:

Resorcinol

Cas Number:

108-46-3

Molecular formula:

C6H6O2

IUPAC Name:

resorcinol

Details on test material:

IUCLID4 Test substance: as prescribed by 1.1 - 1.4

Test animals

Species:

rat

Strain:

other: Harlan-Wistar

Sex:

female

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

not specified

Vehicle:

other:

Duration of exposure:

1 h

Concentrations:

At the 1 hour time interval, rats were exposed to concentrations of 7800 mg/m3 (57.4% weight/unit volume)(1732 ppm) and 2130 mg/mg3 (18.2% weight/unit volume) (473 ppm). It should be noted that in the study conducted at a concentration of 7800 mg/m3, the solution turned milky. And some precipitate was noted.  It is likely that flow concentrations were less than the concentration indicated.

No. of animals per sex per dose:

12 (6 rats per dose)

Details on study design:

The acute toxic effects of catechol-, resorcinol- and phenol-water aerosols were investigated at comparable airborne concentrations.

Samples were dissolved in distilled water and the resulting solutions were aerosolized using a D18 Dautrebande aerosol generator operated at 30 psi.  At this operating pressure, the D18 generator delivered droplets of 1µ or smaller.  The concentration of the sample solutions was adjusted so that the airbourne concentration approximated 2,000 mg/m3 (444 ppm) of the sample in air.  Airborne concentrations were determined by measurement of the volume loss of solution following aerosolization.  The weight of sample present in that volume was then calculated and related to the total volume of air in generating the aerosol to obtain chamber concentrations. In groups of 6, rats, weighing between 87 and 126 g, were subjected to a single 1 hour inhalation period of the aerosolized sample. 

At the 1 hour time interval, rats were exposed to concentrations of 7800 mg/m3 (57.4% weight/unit volume)(1732 ppm) and 2130 mg/mg3 (18.2% weight/unit volume) (473 ppm). It should be noted that in the study conducted at a concentration of 7800 mg/m3, the solution turned milky. And some precipitate was noted.  It is likely that flow concentrations were less than the concentration indicated.

The animals were held for 14 days following exposure and were then weighed and sacrificed for gross necropsy.

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LC0

Effect level:

> 7 800 mg/m³ air

Exp. duration:

1 h

Mortality:

No deaths resulted when rats inhaled resorcinol-water aerosols for one-hour at concentrations of 2,130 mg/M3 (473 ppm) and approx 7,800 mg/M3 (1732 ppm) for a 1 hour period.

Body weight:

All animals had normal 14-day weight gains.

Gross pathology:

No lesions attributable to inhalation of the aerosol were seen at gross necropsy.

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Remarks:

The use of the study for classification is limited as exposure is for only 1 hour.

Conclusions:

No toxic effects are anticipated from acute exposures to resorcinol at aerosol concentrations approximating 7,800 mg/m3 (1732 ppm) for one hour.The classification is limited by the highest concentration tested (1732 ppm), which dictates a classification of Toxicity Category III in accordance with EC 1272/2008 CLP..