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Physical & Chemical properties

Dissociation constant

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Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
Method: other: measured
GLP compliance:
not specified

RS-Freetext:


Study Purpose: Acid Dissociation
Value Type: MEASURED
pK1: 9.32
Remarks: UNCERTAINTY 1-10%

Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
Method: other: no data
GLP compliance:
not specified
Remarks on result:
other: Acid-base constant: pKa = 11.32 at 30 C
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
Method: other: no data
GLP compliance:
not specified
Remarks on result:
other: Acid-base constant: pKa = 9.32 - 11.1
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
Method: other: no data
GLP compliance:
not specified
Remarks on result:
other: Acid-base constant: pKa = 9.15 at 25 °C
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
Method: other: no data
GLP compliance:
not specified
Remarks on result:
other: Acid-base constant: pKa = 9.7 at 25 °C
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
Method: other: no data
GLP compliance:
not specified
Dissociating properties:
yes
Remarks on result:
other: Acid-base constant: pKa = 9.81 at 25 °C

Description of key information

pKa = 9.81 at 25 deg C

Key value for chemical safety assessment

pKa at 20°C:
9.8

Additional information

Schultz (1987)