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Toxicological information

Carcinogenicity

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Description of key information

No evidence of carcinogenic activity was observed when rats and mice were given resorcinol by gavage on 5 days/week for 2 years

Key value for chemical safety assessment

Justification for classification or non-classification

No evidence of carcinogenic activity was observed when rats and mice were given resorcinol by gavage on 5 days/week for 2 years.

Additional information

In a 104 week repeated dose study in 60 male Fischer 344 rats were administered 0, 112, 225 mg/kg bw and 60 female Fischer 344 rats were administered 0, 50, 100 and 150 mg/kg bw resorcinol in water by gavage (NTP, 1992).  Microscopic examination of a comprehensive range of tissues and organs found no increases in the incidence of tumours. Incidences of a variety of neoplasms in high-dose males and nonneoplastic lesions in high-dose males and females were decreased as compared with controls due to the lower survival in the dosed groups.

In a 104 week repeated dose study, 60 male and 60 female B6C3F1 mice were administered 0, 112, 225 mg/kg bw resorcinol in water by gavage (NTP, 1992).  Microscopic examination of a comprehensive range of tissues and organs found no increases in the incidence of tumours.