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EC number: 812-724-1
CAS number: 106705-37-7
A 0.01% suspension of strontium neodecanoate
in polyethylene glycol 400 chosen for the intracutaneous induction stage
revealed a moderate and confluent erythema or discrete or patchy
erythema 24 hours in all 10 test item-treated animals and a discrete or
patchy erythema 48 hours after administration in 4 of the 10 test item-
2 mL of a 10% suspension of strontium
neodecanoate in polyethylene glycol 400/animal chosen for the topical
induction stage were only slightly irritating to the shaved skin in the
preliminary experiment. Hence, in the main study the skin was coated
with sodium lauryl sulfate on the day before topical induction in order
to induce a local irritation. This treatment resulted in a moderate and
confluent erythema 48 hours and a discrete or patchy erythema 72 hours
after start of exposure in all 15 animals (test and control animals).
The challenge with 2 mL of a 5% suspension
of strontium neodecanoate in polyethylene glycol 400 /animal revealed no
skin irritation in any animal and, thus, the test item had no
The vehicle control revealed no skin
reactions during the challenge.
- body weight: body weight gain of the
animals treated with strontium neodecanoate was within the range of the
vehicle control during the experiment.
- clinical signs: behaviour remained
unchanged during the course of the study.
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