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EC number: 812-724-1
CAS number: 106705-37-7
In this study, rats were fed 100 mg/kg/day of neodecanoic acid for 5
days and followed by a pulse of C-14 labeled neodecanoic acid and
assessed every 24 hours for 3 days to determine the distribution and
excretion. It was found that under the conditions of the experiment,
70-80% of the administered activity could be accounted for. Excretion
in the urine may expect to range from 50-60% while that in the feces
will vary from 40-50%. In any case, the total of these two will be at
least 98%. The excretion rate falls off rapidly such that less than 1%
of dose is expected past 72 hours. Expired air reaches a peak rate
somewhere around 12 hours or earlier. The total carcass, exclusive of
organs, retains less than 1% of the recovered dose. Intestines had the
greatest specific activity and contribute as much as 1% of total dose.
Analysis by thin layer chromatography shows that the bulk of excreted
activity is either the original free acid or a material which is readily
converted to the acid upon mild hydrolysis.
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