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EC number: 701-390-1
CAS number: -
of dermal lesions (following 4-h application)
Days after application
Mean score erythema
Mean score oedema
= abnormal fur growth; Fr = reduced fur growth; D = desquamation; T =
thickening of skin; R= reactions extending beyond treatment site; Hy =
hyperkeratinisation; Br = brown discolourisation of skin; L = loss of
skin suppleness; H = haemorrhage of dermal capillaries; Gr = green
discoulorisation of skin; Tf = transverse folding of skin; Fi =
fissuring of skin; Sc = small scattered scabs; Gs = glossy skin, E =
eschar, P = pink coloured and shiny skin
A study was performed to assess the effects
of Amine 760 on the irritancy potential to the skin of the New Zealand
White rabbit. The method used was based on that described in the OECD
Guidelines for Testing of Chemicals (1981) No. 404 "Acute Dermal
A three minute, 1 hour and 4 hours,
semi-occluded dermal application of the test material to the intact skin
of three rabbits followed by a decontamination procedure with acetone
produced irritation scores directly after patch removal and 1,2 and 3
scores for erythema were observed in all animals during first 3 days and
in two animals accompanied by eschar formation even until day 7, with
desquamation in all three animals. At end of observation period on day
14, all animals show pink and shiny skin and in two animals desquamation
is still visible. Although the report indicate no visible necrosis, the
seriousness of the effects, only partial recovery, and pink shiny
colouration indicative of skin recovery after damage, it is probably
prudent to classify as corrosive.
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