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EC number: 701-390-1
CAS number: -
RESULTS: EXPOSED- Nominal/measured concentrations: 0, 0.01, 0.02, 0.04,0.08, 0.16 mg/L (nominal)- Effect data (Immobilisation): Immobile Daphniaconc mg/L 24 hrs 48 hrs 0 0 10.01 0 20.02 1 20.04 0 10.08 0 110.16 9 20The EC50 - 48 hrs was calculated to be 0.078 mg/L with 95% confidence limits of 0.066 and 0.092 mg/L. At 24 hrs noeffects were too low to derive an EC50. The NOEC 48 h amounted to 0.04 mg/L, the LOEC 48 h was 0.08 mg/L. TheEC100 was 0.16 mg/L and was observed after 48 hrs. - Concentration / response curve: -- Cumulative immobilisation: see Effect data(Immobilisation)- Effect concentration vs. test substance solubility: -- Other effects: Sublethal effects were not observed in thetest (concentrations where no immobility was observed).RESULTS CONTROL: see Effect data (Immobilisation)
The acute toxicity of Triameen Y 12
D to Daphnia magna (water flea) was tested under static
conditions for 48 hours in accordance with OECD and EEC guidelines for
testing of chemicals. The test was performed in compliance with Good
Laboratory Practice (GLP). The daphnia were exposed to the
following nominal test concentrations:
0.01 – 0.02 – 0.04 – 0.08 and 0.16 mg/L.The EC50
(48 h) was calculated to be 0.078 mg/L with 95% confidence limits of
0.066 and 0.092 mg/L. The EC100 was 0.16 mg/L, which was
observed after 48 hours. Sublethal effects were not observed in the test
concentrations where no immobility was observed.
Quantification of the applied
concentrations was not possible due to the absence of a suitable
analytical method. The currently available analytical method is capable
of analyzing down to only 10 mg/L. Therefore only the stock solution
used to prepare the test concentrations was analyzed. These analyses
showed that the stock solution was stable even after storage for almost
7 months in the refrigerator. All concentrations mentioned in this
report are therefore based on nominal concentrations. Considering the
high water solubility of the test substance and its stability it is
reasonable to assume that the actual concentrations were identical to
the nominal concentrations during the entire test.
Only a limit number of short-term toxicity to aquatic invertebrates
studies are available for the substances under consideration. Therefore
the test results of a number of alkyl-1,3-diaminopropanes and for
dodecyltriamine Y were added to the dossier. Tri- and tetramines contain
respectively about 22 – 11% diamines and for this reason the data for
the diamines was added to the overview. It is considered reasonable to
add dodecyltriamine Y as a worst-case as this substance is considered a
the most toxic triamine. The study with dodecyltriamine Y is selected as
the Key study as this study is a Klimisch 1. The LC50 of this study is
therefore used as the Key value for chemical safety assessment as a
reasonable worst-case. In the final risk assessment this value will not
be critical as two chronic end points are available.
Most of the short-term
toxicity daphnia tests were conducted in a period when no reliable
specific method of analyses was available. The concentrations were
therefore not analytically verified, the reliability of the results is
limited because of the poor solubility of the test substances and
partial sorption onto the walls of test vessels. Hence, most of the
tests were considered to be valid with restrictions. Only one acute
daphnia test study is available with a Klimisch 1 which is for N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine
(2372-82-9; dodecyltriamine Y).
This substanceis used as a
biocide and this substance is considered as the most ecotoxic substance
for the alkyl triamines (3N).The
observed LC50 for this substance of 0.0775 mg/L, suggests that the
alkyl-1,3-diaminopropanes (2N) are more ecotoxic than the alkyl
polyamines (>2N). Tri- and
tetramines contain respectively about 22 – 11% diamines and for this
reason the data for the diamines was added to the list of tests.
For oleyl tetramine (4N) an EC50 (48 h) has been observed of 0.032 mg/L.
This value is slightly lower than the value observed for dodecyltriamine
Y. For oleyl triamine a long term test result is available with specific
chemical analysis which is used for the hazard assessment because the
results can be used for the bulk approach where the sorption to
glassware was minimal and solution stability much better.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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