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EC number: 701-390-1
CAS number: -
The safety assessment according to Annex 1 does not indicate the need to
investigate further the effects on aquatic organisms. Therefore no
chronic fish testing is required.
The safety assessment according to
Annex 1 does not indicate the need to investigate further the effects on
aquatic organisms. Therefore no chronic fish testing is required. In
addition, fish are in general less sensitive to cationic surfactants as
observed for linear alkyl diamines or quats compared to algae and
daphnia. The available acute fish data for the diamines category which
covers an alkyl chainlength range from C12 to C18 reveal a comparable
toxicity, independent of this alkyl chain length. The available acute
fish LC50 of 0.43 mg/L for a dodecyltriamine Y which is used as a
biocide and therefore considered as one of the more toxic in the
For the calculation of the
PNECaquatic bulk it is considered unlikely that fish toxicity will be
critical for alkyl polypropylenepolyamines. Hence any additional
toxicity testing with fish will not add scientific value to the
ecotoxicity profile of the alkyl polypropylenepolyamines other than for
obtaining a lower assessment factor. It is therefore concluded that for
scientific reasons and in accordance to REACH legislation further
testing on fish has to be avoided for reasons of animal welfare and that
based on the weight of evidence available on ecotoxicity data for
several cationic surfactants a safety factor of 10 may be applied for
the derivation of the PNECaquatic,bulk.
use of an assessment factor of 10 is supported by the low acute to
chronic ratio observed in the long-term daphnia test. The daphnia
reproduction test result shows that at the highest test concentration
all parental daphnids were immobile within four days, without
reproduction, except for one daphnia which continued reproducing
normally for the triamines, while at the next concentration there
is not only no immobilisation, but there is no detrimental effect on
reproduction when compared to the control. These observations result in
a low acute-to-chronic ratio. A low acute-to-chronic ratio is indicative
of a non-specific mode of action and is often associated with not
systemic effects. This observation is consistent with the known effects
of cationic surfactants on aquatic organisms, where toxicity is
associated with physical binding to respiratory membranes. This explains
the steep concentration curves seen and the lack of intermediate chronic
effects on reproduction.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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