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EC number: 701-390-1
CAS number: -
Starting point NOAEL 90-day on Tallow
dipropylenetriamine: 2.5 mg/kgbw/d; The corrected 8 hr inhalation NOAEC
for workers is NOAEL(2.5 mg/kg) * 1.76 mg/m3 = 4.4 mg/m3. No factor 2
route extrapolation from oral to inhalation. Due to very low vp (less
than 4.7 x 10-5 Pa at 20°C), exposure is only possible as aerosol or
larger particles. If any inhalation does occur, this can only be in the
form of larger droplets, as the use does not include fine spraying.
Droplets will deposit mainly on upper airways, and will be subsequently
swallowed following mucociliary transportation to pharynx. This results
to no principal difference in absorption compared oral route.
Starting point is the NOAEL from 90-day
study on Tallow dipropylenetriamine: 2.5 mg/kgbw/d At this stage no data
are available on dermal absorption. Polyamines are not expected to
easily pass the skin in view of its ionised form at physiological
conditions. However, as this is not quantitatively evaluated, 100%
dermal absorption (i.e. similar as oral) is considered as worst case
These substances are only used in an industrial setting applying adequate PPE. The substance is not used in the consumer sector and consumers/general population will not be exposed. Assessment of indirect exposure is not needed as the tonnage is not above 1000 tpa, and the substance is not classified as CMR or toxic (R48 or STOT-RE 1).
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