Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-390-1
CAS number: -
is corrosive to skin, no in vivo sensitisation study needs to be
performed. There are no structural concerns for sensitisation, and
cross-reading to data from structurally related substances also do not
show a concern. Due to use in industrial and professional setting only,
with the application of adequate Personal Protection Measures related to
the severe corrosive properties of the diamines, exposures are limited.
There are no reports on incidents of sensitisation to diamines available.
As indicated in REACH Annex VII, an in
vivo skin sensitisation study does not need to be conducted as the
substance is classified as corrosive to the skin. Available data
indicate that Tallow tripropylenetetraamine is corrosive to the skin.
There are no consumer exposures, only industrial/professional use under
circumstances involving the use of PPM following the classification as
corrosive cat. 1B. Consequently, due to limited exposures, animal
testing is not required.
Additionally, the molecular structure
of the Tallow dipropylenetriamine does not contain toxicophores
indicating a concern for sensitization. Primary fatty amines are
recognised as not sensitising. Available QSARs indicate possible
sensitising properties based on structural similarities with ethylene
amines known to have sensitising properties, and some other structural
similar substances that actually do have protein binding properties, and
as such are not considered to be predictive for the polyamines.
The profiling of alkyl-diamines (QSAR
Toolbox v.3.0) indicates that no alerts are found for protein binding,
thiol reactivity is not expected, and that the structure is not
represented among the categories of high, moderate or low reactivity in
DPRA (direct peptide reactivity assays) for either cysteine or lysine
depletion. Additionally, the molecular structure of the diamines does
not contain toxicophores indicating a concern for sensitization, and
also read across to data available on structurally related branched
triamine (Dodecyl dipropylene triamine) and primary amines in general do
not indicate a concern.
There are noreports on incidences of
sensitisation from industrial production and use of the substance.
As chemical respiratory sensitisers
also elicit positive results in predictive tests for contact
sensitisation, a negative prediction for dermal sensitisation would also
be predictive for non-respiratory sensitisation of the substance. As
indicated, the molecular structure of the polyamines does not contain
toxicophores indicating a concern for sensitization, and also read
across to data available on structurally related branched dipropylene
triamines and primary amines in general do not indicate a concern.
Consequently, respiratory sensitisation is not expected from polyamines.
Based on limited exposures by dermal route
(substance is very corrosive) or by inhalation (very low vapour
pressure) and results from a structurally related triamine showing no
sensitisation, as well as lack of toxicophores
in the structure of polyamines indicating a concern for sensitisation,
there are no concerns for sensitisation expected.
as a firm conclusion from a study with this compound is lacking, no
definite conclusion might be drawn for classification purposes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
På den här webbplatsen används kakor. Syftet är att optimera din upplevelse av den.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again