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EC number: 701-390-1
CAS number: -
Three groups of Wistar rats; each comprising
2 males and 2 females, received a single oral dose at 25, 200 and 2000
mg/kg body weight; respectively. The incidence of mortalities for the
sexes combined from low to high dose group was 0, 0 and 4. There was no
evident sex related effect. All deaths occurred within 1 day of dosing.
Signs of toxicity in animals of the high dose group were lethargy and a
rough fur. No abnormal clinical behaviour was observed in animals of the
25 mg/kg and 200 mg/kg dose groups and no abnormalities at necroscopy.
Group mean body weight gain for animals of the low and mid dose groups
was nomal. Macroscopic examination of animals at necropsy revealed in
all animals of the high dose group petechiae of the stomach, a yellow
liquid intestinal content and gas accumulation in the intestines.
Based on the absence of signs of toxicity in
the 200 mg/kg group as well as the absence of abnormalities in this
group at necroscopy, it is considered unlikely that mortality would
occur between 200 and 300 mg/kg. The anticipated LD50 would therefore be
> 300 mg/kg, hence classified in Category 4.
Although not indicated in the report, for
classification purposes for use in mixtures a LD50 cut-off value of 500
mg/kgbw is suggested.
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