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EC number: 701-390-1
CAS number: -
The equilibrium partitioning method (EPM) has provisionally been used to
calculate the PNEC for benthic organisms using a Kp susp-water of 100000
equilibrium partitioning method (EPM) can be used as a screening tool to
help determine whether sediment toxicity tests with benthic organisms
are required. This equilibrium partitioning concept has been shown to be
relevant for nonpolar hydrophobic contaminants, but the validity of this
concept for ionic compounds has hardly been studied. Chen, Y et al 2014
therefore studied if the equilibrium partitioning concept is also
applicable to the cationic surfactant C12 benzalkonium chloride. Chen
found that based on the results of 4 different bioassays, the
equilibrium partitioning is also valid for this specific cationic
To evaluate the applicability of the EPM
for predicting the hazard for benthic organisms when exposed to cationic
surfactants, the available test results from long term daphnia NOEC/EC10
and long term lumbriculus/chironomid NOEC/EC10 for a number of cationic
surfactants were compared using the observed sorption/desorption data
(not normalized for OC content) and the EPM.
The comparison shows that for all
substances evaluated the EPM predicted hazard for sediment organisms is
more conservative than what is actually observed. For 50% of the
substances the ratio predicted/observed NOEC/EC10 lies between 0.5 and
0.9. For the other 50% this ratio lies between 0.02 and 0.5. These
findings confirm that the EP approach conservatively predicts the
benthic hazard due to exposure to cationic surfactants and that it can
savely be used as a screening tool for cationic surfactants.
It should be noted that the Kp
susp-water of the substances evaluated ranged from 1000 to 17000 L/kg
and that despite of these high sorption constants a conservative hazard
for the benthic compartment was predicted.
According to REACH guidance R.16 the EPM
uses the PNECaquaticand the sediment/water partitioning
coefficient as inputs. However, since the available PNECaquaticis
based on the bulk concentration present in surface water a
re-calculation is necessary first:
dissolved = PNECaquatic
bulk/ (1 + Kpsusp* SUSPwater* 10-6)
bulk = 14.24
Kpsusp = 100000
SUSPwater = 15
The PNECsed is then
calculated using the equations detailed in the TGD:
PNECsed = Ksusp-water*
PNECaquatic dissolved* 1000 * 1 / RHOsusp
dissolved = 5.7
Ksusp-water = 25000
RHOsusp = 1150
kg/m3(TGD, eq. 18)
= 123.8 mg/kg ww
To compensate for additional exposure
via ingestion an additional factor of 10 can be applied.
= 12.4 mg/kg ww or 57
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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