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Ecotoxicological information

Toxicity to birds

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Reference
Endpoint:
toxicity to birds
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Principles of method if other than guideline:
90-d toxicity on birds, sub-chronic dietary exposure.
GLP compliance:
not specified
Dose method:
feed
Analytical monitoring:
yes
Vehicle:
no
Test organisms (species):
Colinus virginianus
Total exposure duration (if not single dose):
90 d
No. of animals per sex per dose and/or stage:
5
Control animals:
yes, plain diet
Duration (if not single dose):
90 d
Dose descriptor:
other: LOAEL
Effect level:
ca. 178 mg/kg bw/day
Conc. / dose based on:
test mat.
Basis for effect:
mortality
Duration (if not single dose):
90 d
Dose descriptor:
other: NOAEL
Effect level:
>= 7 mg/kg bw/day
Conc. / dose based on:
test mat.
Basis for effect:
mortality

Description of key information

Based on the results of this 90-d study, a low observedadverse- effect level in the serious category (i.e., due to the incidence of mortality) was determined to be 178 mg/kg/d. Acknowledging the limitations of this study, we estimated a no-observable-adverse-effect level (NOAEL) of 7 mg/kg/d. We wish to point out that this NOAEL may be an underestimation of the true NOAEL and that other target tissues (e.g., CNS) will need to be investigated to increase confidence in the present estimated NOAEL in TNT-exposed birds

Key value for chemical safety assessment

Long-term EC10, LC10 or NOEC for birds:
7 mg/kg food

Additional information